5.38763

CD38 Inhibitor

≥98% (HPLC), solid, CD38 inhibitor, Calbiochem^®

• Sinônimo(s): CD38 Inhibitor, Compound 78c, CD38i_78c, 78c, Cluster of Differentiation 38 Inhibitor
• Fórmula empírica (Notação de Hill): C₂₂H₂₇N₃O₃S
• Número CAS: 1700637-55-3
• Peso molecular: 413.53
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• product name: CD38 Inhibitor,
• Ensaio: ≥98% (HPLC)
• Nível de qualidade: 100
• forma: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: light brown to brown; white to light brown
• solubilidade: DMSO: 100 mg/mL
• temperatura de armazenamento: 2-8°C

Descrição

Descrição geral

A cell-permeable, orally bioavailable, non-toxic thiazolyl-quinolinone derived compound that acts as a potent, selective and reversible inhibitor of CD38 (IC₅₀ = 7.3 & 1.9 nM for human & mouse CD38, respectively; K_i = 0.3 nM for human wt-CD38). Shown to bind to the catalytic active site. Displays attractive PK properties in mice (p.o. 30 mg/kg: t_1/2 = 3.5 h, C_max = 10.8 µg/ml; i.v. 2 mg/kg: t_1/2 = 5.3 h, C_max = 2.98 µg/ml, Cl = 21 ml/min/kg, Vdss = 1.3 L/kg). Rapidly elevates NAD levels by several folds in both liver and gastrocnemius tissue in a diet induced obese mouse (30 mg/kg, p.o.).

Ações bioquímicas/fisiológicas

Cell permeable: yes

Primary Target
CD38

Reversible: yes

Target IC₅₀: 7.3 & 1.9 nM for human & mouse CD38, respectively

Embalagem

Packaged under inert gas

Advertência

Toxicity: Standard Handling (A)

Outras notas

Haffner, C.D., et al. 2015. J. Med. Chem.58, 3548.
Tarrago, M.G., et al. 2018 Cell. Metab.27, 1081.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable