5.00670

FATP2 Inhibitor, CB-2

• Sinônimo(s): FATP2 Inhibitor, CB-2, (5E)-5-((3-bromo-4-hydroxy-5-methoxyphenyl)methylene)-3-(3-chlorophenyl)-2-thioxothiazolidin-4-one, CB2, Fatty Acid Transport Protein 2 Inhibitor
• Fórmula empírica (Notação de Hill): C₁₇H₁₁BrClNO₃S₂
• Peso molecular: 456.76
• Código UNSPSC: 41106300
• NACRES: NA.77

Propriedades

• Ensaio: ≥99% (HPLC)
• Nível de qualidade: 100
• Formulário: solid
• potência: 8 μM IC₅₀
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: yellow
• solubilidade: DMSO: 50 mg/mL
• temperatura de armazenamento: 2-8°C

Descrição

Descrição geral

A cell permeable thioxothiazolindine compound that reversibly inhibits FATP2- (fatty acid transport protein 2) mediated long chain fatty acid uptake in Caco-2 and HepG2, but not non-FATP2-expressing 3T3-L1 adipocytes, cultures (IC₅₀ against C₁-BODIPY-C₁₂ = 3.99, 7.55, and 231.1 µM, respectively), exhibiting much reduced potency toward cellular Acsl (acyl-CoA synthetase) activity (IC₅₀ = 50 µM using lysates from 1h inhibitor-treated Caco-2 cells). Shown not to affect Caco-2 viability (50 µM in MTT assay), membrane permeability (by trans-epithelial electrical resistance measurement; 50 µM), glucose transport (20 µM in 2-NBDG uptake assay).

A cell permeable thioxothiazolindine compound that reversibly inhibits FATP2-mediated long chain fatty acid uptake in Caco-2 and HepG2, but not non-FATP2-expressing 3T3-L1 adipocytes, cultures (IC₅₀ = 3.99, 7.55, and 231.1 µM, respectively), while exhibiting much reduced potency toward cellular Acsl (acyl-CoA synthetase) activity (IC₅₀ = 50 µM). Shown not to affect Caco-2 viability, membrane permeability, or glucose transport.

Ações bioquímicas/fisiológicas

Cell permeable: yes

Advertência

Toxicity: Standard Handling (A)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Sandoval, A., et al. 2010. Biochem. Pharmacol.79, 99.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable