344273-M

Forskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-, Dihydrochloride

Chemically-modified forskolin with greater stability and water solubility than the parent compound.

• Sinônimo(s): Forskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-, Dihydrochloride, L-858051, 8,13-Epoxy-7β-(N-methylpiperazino-γ-butyryloxy)-1α,6β,9α-trihydroxy-labd-14-en-11-one, 2HCl
• Fórmula empírica (Notação de Hill): C₂₉H₄₈N₂O₇ · 2HCl
• Número CAS: 115116-37-5
• Peso molecular: 609.62
• Código UNSPSC: 12352200

Propriedades

• Nível de qualidade: 200
• Ensaio: ≥92% (HPLC)
• forma: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; desiccated (hygroscopic)
• cor: white
• solubilidade: water: 12 mg/mL; methanol: soluble
• temperatura de armazenamento: 10-30°C

Descrição

Descrição geral

A chemically modified forskolin with greater stability and water solubility. Activates adenylate cyclase (EC₅₀ = 13 µM).

Chemically-modified forskolin with greater stability and water solubility than the parent compound. Activates adenylate cyclase (EC₅₀ = 13 µM). Inhibits 5HT-stimulated inositol phosphate accumulation in smooth muscle cells.

Ações bioquímicas/fisiológicas

EC50 = 13 µM in activating adenylate cyclase

Primary Target
Adenylate cyclase

Advertência

Toxicity: Harmful (C)

Reconstituição

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 4 months at 4°C.

Outras notas

Yang, C.M., et al. 1999. Cell Signal. 11, 697.
Hartzell, H.C., and Budnitz, D. 1992. Mol. Pharmacol.41, 880.
Chidiac, P., et al. 1991. J. Mol. Cell. Cardiol.23, 1255.
Laurenza, A., et al. 1987. Mol. Pharmacol.32, 133.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable