264103

Desoxicolato de sódio

ULTROL^® Grade, ≥99% (TLC), detergent to solubilize membrane-bound proteins in their native state

• Sinônimo(s): Ácido 3α,12α-Di-hidroxi-5β-colânico, Ácido 7-desoxicólico, Ácido desoxicólico
• Fórmula empírica (Notação de Hill): C₂₄H₃₉NaO₄
• Número CAS: 302-95-4
• Peso molecular: 414.55
• Beilstein: 3581950
• Número MDL: MFCD00064139
• Código UNSPSC: 12161902
• NACRES: NA.21

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥99% (TLC)
• forma: solid
• peso molecular: micellar avg mol wt 1200-5000; micellar wt 1200-4900
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; desiccated (hygroscopic)
• número de agregação: 3 - 12; 3-12
• cor: white
• pKa: 6.2
• CMC: 2 - 6 mM; 2-6 mM (20-25°C)
• HLB: 16
• Condições de expedição: ambient
• temperatura de armazenamento: 15-25°C
• cadeia de caracteres SMILES: [Na+].[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@H]([C@H](C)CCC([O-])=O)[C@@]4(C)[C@@H](O)C[C@]3([H])[C@@]1(C)CC[C@@H](O)C2
• InChI: 1S/C24H40O4.Na/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3;/h14-21,25-26H,4-13H2,1-3H3,(H,27,28);/q;+1/p-1/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-;/m1./s1
• chave InChI: FHHPUSMSKHSNKW-SMOYURAASA-M

Descrição

Descrição geral

Absorbance (10%, H₂O, 290 nm):≤0.25.

Highly purified and intended for use as a detergent to solubilize membrane-bound proteins in their native state (absorbance: <0.25 at 290 nm, 10% H₂O; aggregation number: 3-12; CMC: 2-6 mM; micellar weight: 1200-4900; pK_a: 6.2). Reported to induce tyrosine phosphorylation of β-catenin and its subsequent translocation to the nucleus, promoting activation of β-catenin signaling (effective concentration 5-50 µM).

Highly purified and intended for use as a detergent to solubilize membrane-bound proteins in their native state. Reported to induce tyrosine phosphorylation of β-catenin and its subsequent translocation to the nucleus, promoting activation of β-catenin signaling (effective concentration 5-50 µM). Aggregation number: 3-12.

Aplicação

• Treatment of mucocutaneous leishmaniasis - A systematic review.: Sodium deoxycholate is discussed in this systematic review as a component in treatment regimens for mucocutaneous leishmaniasis, offering comprehensive insights into current therapeutic approaches and outcomes (Fischer et al., 2024).

Advertência

Toxicity: Harmful (C)

Nota de preparo

Do not use with Mn²⁺ in solution.

Reconstituição

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C. Discard if bacterial or fungal growth is observed.

Outras notas

Pai, R., et al. Mol. Biol. Cell15, 2156.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

ULTROL is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302
• Declarações de precaução: P264 - P270 - P301 + P312 - P501
• Classificações de perigo: Acute Tox. 4 Oral
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable