182015

Cyclo(Arg-Gly-Asp-D-Phe-Val)

Potent inhibitor of cell adhesion.

• Sinônimo(s): Cyclo(Arg-Gly-Asp-D-Phe-Val), RGDFV Peptide, Cyclic
• Fórmula empírica (Notação de Hill): C₂₆H₃₈N₈O₇
• Número CAS: 137813-35-5
• Peso molecular: 574.63
• Código UNSPSC: 12352202
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥95% (HPLC)
• forma: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; desiccated (hygroscopic)
• cor: white
• solubilidade: 1 N acetic acid: 5 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: −20°C

Descrição

Descrição geral

Potent inhibitor of cell adhesion. Inhibits tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations in rats showed it to be useful in the amelioration of ischemic acute renal failure in rats. Also inhibits tubular obstruction by preventing cell-cell adhesion. Inhibits the redistribution of c-Src into focal adhesions, thereby leading to impaired MAP Kinase activation.

Potent inhibitor of cell adhesion. Inhibits tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations showed it to be useful in the amelioration of ischemic acute renal failure in rats. Also inhibits tubular obstruction by preventing cell-cell adhesion.

Ações bioquímicas/fisiológicas

Cell permeable: no

Primary Target
inhibits tumor cell adhesion to laminin and vitronectin substrates

Product does not compete with ATP.

Reversible: no

Advertência

Toxicity: Standard Handling (A)

Outras notas

Shono, T., et al. 2001. Exp. Cell Res.268, 169.
Matsuno, H., et al. 1994. Circulation 90, 2203.
Noiri, E., et al. 1994. Kidney Int. 46, 1050.
Gurrath, M., et al. 1992. Eur. J. Biochem. 210, 911.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable