14-557-M
B-Raf (V599E) Protein, active, 10 µg
Active, N-terminal GST-tagged recombinant human B-Raf residues 416-end, containing a V599E mutation, for use in Kinase Assays.
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About This Item
Código UNSPSC:
12352202
eCl@ss:
32160405
NACRES:
NA.41
Produtos recomendados
fonte biológica
human
Nível de qualidade
recombinante
expressed in baculovirus infected Sf21 cells
peso molecular
Mw 67.3 kDa
fabricante/nome comercial
Upstate®
técnica(s)
activity assay: suitable (kinase)
nº de adesão NCBI
nº de adesão UniProt
Descrição geral
N-terminal GST-tagged recombinant human B-Raf residues 416-end, containing a V599E mutation (also designated V600E)
Product Source: Expressed by baculovirus in Sf21 insect cells
Aplicação
Research Category
Inflammation & Immunology
Inflammation & Immunology
Ações bioquímicas/fisiológicas
Protein Target: B-Raf
Target Sub-Family: TKL
Embalagem
Also available in 250 µg size --call for pricing and availability and reference catalog number 14-557M when ordering the 250 µg size.
Qualidade
routinely evaluated by phosphorylation of MBP substrate in vitro
forma física
Glutathione agarose affinity chromatography
Armazenamento e estabilidade
6 months at -70°C
Outras notas
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Informações legais
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Palavra indicadora
Warning
Frases de perigo
Declarações de precaução
Classificações de perigo
Skin Sens. 1
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 2
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
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Cancer cell, 6(4), 313-319 (2004-10-19)
RAF proteins are components of a conserved signaling pathway that regulates cellular responses to extracellular signals. Despite over 20 years of research into the regulation and function of the RAF proteins, it was only realized recently that the B-RAF isoform
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Cell, 116(6), 764-766 (2004-03-24)
A study by Wan et al. in this issue of Cell demonstrates that the majority of oncogenic mutations in the B-Raf protein kinase result in increased catalytic activity, through disruption of the autoinhibited state of the kinase domain. Surprisingly, several
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Biochimica et biophysica acta, 1653(1), 25-40 (2003-06-05)
A recent report has shown that activating mutations in the BRAF gene are present in a large percentage of human malignant melanomas and in a proportion of colon cancers. The vast majority of these mutations represent a single nucleotide change
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