119149

Adenosine A2A Receptor Antagonist I, ZM 241385

A highly potent, selective, non-xanthine adenosine A2A receptor antagonist (K_i = 800 pM for human adenosine A2AR stably expressed in HEK-293 cells).

• Sinônimo(s): Adenosine A2A Receptor Antagonist I, ZM 241385
• Fórmula empírica (Notação de Hill): C₁₆H₁₅N₇O₂
• Número CAS: 139180-30-6
• Peso molecular: 337.34
• Número MDL: MFCD00908394
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• potência: 800 pM K_i
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: white
• solubilidade: DMSO: 15 mg/mL
• aplicação(ões): air monitoring
• compatibilidade: for use with Viable Air Samplers (1.09191); for use with Viable Air Samplers (1.09194); for use with Viable Air Samplers (1.17103); for use with Viable Air Samplers (1.17274); for use with Viable Air Samplers (1.17275)
• Condições de expedição: ambient
• temperatura de armazenamento: 2-8°C
• InChI: 1S/C16H15N7O2/c17-14-20-15(18-8-7-10-3-5-11(24)6-4-10)21-16-19-13(22-23(14)16)12-2-1-9-25-12/h1-6,9,24H,7-8H2,(H3,17,18,19,20,21,22)
• chave InChI: PWTBZOIUWZOPFT-UHFFFAOYSA-N

Descrição

Descrição geral

A highly potent, selective, and orally bioavailable non-xanthine adenosine A_2A receptor antagonist (K_i = 800 pM for human adenosine A_2AR stably expressed in HEK-293 cells). Does not exhibit any significant antagonistic activity in A₁, A_2B (K_i = 255 nM and 50 nM, respectively in human adenosine receptors stably expressed in CHO cells) or in A₃R (K_i >10 µM in human A₃R stably expressed in HEK-293 cells). Shown to have a protective effect against beta-amyloid peptide toxicity.

A highly potent, selective, non-xanthine adenosine A2A receptor antagonist (K_i = 800 pM for human adenosine A2AR stably expressed in HEK-293 cells).

Ações bioquímicas/fisiológicas

Primary Target
A2A

Reversible: yes

Advertência

Toxicity: Standard Handling (A)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Poucher, S. M., et al. 1995. Brit. J. Pharmacol. 115, 1096.
Ongini, E. et al. 1999. Naunyn Schmiedebergs Arch Pharmacol. 359, 7.

Keddie, J. et al. 1996, Eur Journ Pharm. 301, 107.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable