07-689
Anti-EZH2 Antibody
Upstate®, from rabbit
Sinônimo(s):
KMT6, Enx1, Enhancer of Zeste Homologue 2
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Produtos recomendados
fonte biológica
rabbit
Nível de qualidade
forma do anticorpo
whole antiserum
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
reatividade de espécies
human, mouse
embalagem
antibody small pack of 25 μL
fabricante/nome comercial
Upstate®
técnica(s)
ChIP: suitable (ChIP-seq)
immunoprecipitation (IP): suitable
western blot: suitable
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
ambient
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... EZH2(2146)
Descrição geral
Polycomb protein group complexes are responsible for the regulation of hundreds of genes in mammals and insects. These proteins are responsible for the assembly and packaging of chromatin and for the induction of methylation on Histone H3. EZH2 (enhancer of zeste homologue 2) is a member of the polycomb group of proteins and is involved in cell cycle regulation. EZH2 represses transcription via trimethylation of histone H3 on Lys27 (H3K27) as indicated by the fact that RNAi-mediated knockdown of EZH2 resulted in a loss of H3K27 trimethylation. The expression of this protein in human tumors is aggressive for hormone refractory prostate cancer. In breast cancer EZH2 expression was increased in malignant tumors and promoted anchorage independent and invasive growth in vitro.
Especificidade
EZH2
Imunogênio
His-tagged fusion protein corresponding to residues 1-343 of mouse enhancer of Zeste homolog 2 (EZH2)
Aplicação
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Histones
Histones
This Anti-EZH2 Antibody is validated for use in Immunoprecipitation and Western Blotting and ChIP-seq for the detection of EZH2.
Qualidade
routinely evaluated by immunoblot on RIPA lysates from HeLa and C2C12 cells
Descrição-alvo
95-100kDa
forma física
Antiserum
Format: Purified
Armazenamento e estabilidade
stable for 2 years at 2-8°C from date of shipment
Nota de análise
Control
K562 cell lysate, C2C12 cell lysate
K562 cell lysate, C2C12 cell lysate
Outras notas
Please refer to lot specific datasheet.
Informações legais
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Nº do produto
Descrição
Preços
Código de classe de armazenamento
12 - Non Combustible Liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
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Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators.
Landeira, David, et al.
Nature Cell Biology, 12, 618-624 (2010)
Heterogeneity of chromatin modifications in testicular spermatocytic seminoma point toward an epigenetically unstable phenotype.
Dina G Kristensen,Olga Mlynarska,John E Nielsen,Grete K Jacobsen,Ewa Rajpert-De Meyts et al.
Cancer Genetics null
Aranzazu Villasante et al.
Theranostics, 6(8), 1119-1130 (2016-06-10)
There is a growing interest in the pivotal role of exosomes in cancer and in their use as biomarkers. However, despite the importance of the microenvironment for cancer initiation and progression, monolayer cultures of tumor cells still represent the main
Transcriptional regulation of Oct4 by a long non-coding RNA antisense to Oct4-pseudogene 5.
Hawkins, PG; Morris, KV
Transcription null
Sodium arsenite represses the expression of myogenin in C2C12 mouse myoblast cells through histone modifications and altered expression of Ezh2, Glp, and Igf-1.
Hong, GM; Bain, LJ
Toxicology and Applied Pharmacology null
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