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Merck
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Key Documents

L-010

Supelco

Levomethorphan

vial of 10 mg, certified reference material, Cerilliant®

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About This Item

Fórmula empírica (Notação de Hill):
C18H25NO
Número CAS:
Peso molecular:
271.40
Número CE:
Código UNSPSC:
41116107
NACRES:
NA.24

grau

certified reference material

forma

solid

Características

Snap-N-Spike®/Snap-N-Shoot®

embalagem

vial of 10 mg

fabricante/nome comercial

Cerilliant®

controle de medicamentos

USDEA Schedule II; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

técnica(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

aplicação(ões)

forensics and toxicology

formato

neat

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

COc1ccc2C[C@@H]3[C@@H]4CCCC[C@]4(CCN3C)c2c1

InChI

1S/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18+/m0/s1

chave InChI

MKXZASYAUGDDCJ-CGTJXYLNSA-N

Descrição geral

A Certified Reference Material suitable for use in LC/MS or GC/MS applications from urine drug testing and clinical toxicology to forensic analysis. Levomethorphan, the l-enantiomer of methorphan, is an opioid analgesic.

Aplicação


  • Enantioselective analysis of Levomethorphan: Development of a novel enantioselective high-performance liquid chromatography-mass spectrometry method for the differentiation of dextro- and levo-methorphan and their O-demethylated metabolites in human blood, applicable to post-mortem samples, highlighting its role in forensic toxicology (Jorbenadze et al., 2024).

  • Quantitative determination in forensic samples: An enantioselective high-performance liquid chromatography-tandem mass spectrometry method was developed for the quantitative determination of methorphan and its O-demethylated metabolite in human blood, demonstrating Levomethorphan′s application as a reference standard in post-mortem forensic analysis (Lo Faro et al., 2023).

  • Chiral analysis in human hair: A study on chiral analysis of dextromethorphan and levomethorphan in human hair by liquid chromatography-tandem mass spectrometry, providing insights into their presence and metabolism in biological samples (Ji et al., 2022).

  • Chiral purity determination: Development of a capillary electrophoresis method for the determination of the chiral purity of dextromethorphan using a dual selector system and quality by design methodology, enhancing the analytical capabilities for Levomethorphan (Krait et al., 2018).

  • Metabolic study on chiral drugs: A metabolic study on the biochemical effects of chiral illegal drugs, including Levomethorphan, in rats using (1)H-NMR spectroscopy, contributing to understanding its biochemical behavior and potential impacts (Fukuhara et al., 2017).

Informações legais

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictogramas

Exclamation mark

Palavra indicadora

Warning

Frases de perigo

Declarações de precaução

Classificações de perigo

Acute Tox. 4 Oral

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


Certificados de análise (COA)

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