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A-096

Supelco

Aldosterone solution

100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

Sinônimo(s):

Aldosterone, 11β,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al, 11β,21-Dihydroxypregn-4-ene-3,18,20-trione, 18-Aldocorticosterone, Reichstein X

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About This Item

Fórmula empírica (Notação de Hill):
C21H28O5
Número CAS:
52-39-1
Peso molecular:
360.44
Beilstein:
3224996
Número CE:
200-835-2
Número MDL:
MFCD00051136
Código UNSPSC:
41116107
ID de substância PubChem:
329770641
NACRES:
NA.24

grau

certified reference material

Nível de qualidade

300

Formulário

liquid

Características

SNAP-N-SPIKE®, SNAP-N-SHOOT®

embalagem

ampule of 1 mL

fabricante/nome comercial

Cerilliant®

concentração

100 μg/mL in acetonitrile

técnica(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

aplicação(ões)

clinical testing
clinical testing

Formato

single component solution

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@H](C(=O)CO)[C@]4(C[C@H](O)[C@H]23)C=O

InChI

1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1

chave InChI

PQSUYGKTWSAVDQ-ZVIOFETBSA-N

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Categorias relacionadas

Descrição geral

Aldosterone is a hormone in the mineralocorticoid family which stimulates sodium transport across cell membranes and assists in the maintenance of blood pressure and blood volume. Aldosterone levels in serum/plasma and urine are measured by LC-MS/MS for investigation of primary or secondary aldosteronism ranging from adrenal cortical hyperplasia to renovascular disease and Bartter′s syndrome.

Aplicação

The d-isomer of aldosterone is considered to be the biologically active isomer.

Outras notas

Exists as an equilibrium mixture of the aldehyde and the hemiacetal.

Informações legais

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Pictogramas

FlameExclamation mark
GHS02,GHS07

Palavra indicadora

Danger

Classificações de perigo

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Código de classe de armazenamento

3 - Flammable liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

35.6 °F - closed cup

Ponto de fulgor (°C)

2 °C - closed cup

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Certificados de análise (COA)

Lot/Batch Number

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Supelco

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3α,5β-Tetrahydroaldosterone ≥98% (CP)

Sigma-Aldrich

750026

3α,5β-Tetrahydroaldosterone

Katy Sánchez-Pozos et al.
Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion, 64(6 Pt 1), 546-557 (2013-03-22)
The vascular endothelium is a dynamic tissue that is sensitive to physical and chemical stimuli. The fact that endothelial cells are directly exposed to the blood fluid components provides the ability to regulate diverse physiological functions, among them are: the
Carine Gennari-Moser et al.
Hypertension (Dallas, Tex. : 1979), 61(5), 1111-1117 (2013-03-06)
Aldosterone levels are markedly elevated during normal pregnancy but fall even though volume contracts when preeclampsia occurs. The level of aldosterone in either condition cannot be explained solely by the activity of the renin-angiotensin II system. In normal gestation, vascular
Aldosterone, vascular endothelial growth factor, and preeclampsia: a mystery solved?
Christian Delles et al.
Hypertension (Dallas, Tex. : 1979), 61(5), 958-960 (2013-03-06)
Teresa Duda et al.
Biochemistry, 52(13), 2337-2347 (2013-03-08)
ANF-RGC is the prototype membrane guanylate cyclase, both the receptor and the signal transducer of the hormones ANF and BNP. After binding them at the extracellular domain, it, at its intracellular domain, signals activation of the C-terminal catalytic module and
Baojian Xue et al.
Hypertension (Dallas, Tex. : 1979), 61(6), 1255-1262 (2013-04-24)
The identification of the specific estrogen receptor (ER) subtypes that are involved in estrogen protection from hypertension and their specific locations in the central nervous system is critical to our understanding and design of effective estrogen replacement therapies in women.
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Protocolos

LC/MS/MS Analysis of Steroid Hormones in Plasma

The conversion of clinical methods to LC/MS/MS offers advantages; however, is accompanied by a few limitations, notably interference effects from the endogenous sample matrix.

Global Trade Item Number

SKUGTIN
A-096-1ML4061833326336

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