830842C

08:0 PA

1,2-dioctanoyl-sn-glycero-3-phosphate (sodium salt), chloroform

• Sinônimo(s): PA(8:0/8:0)
• Fórmula empírica (Notação de Hill): C₁₉H₃₆O₈PNa
• Número CAS: 321883-54-9
• Peso molecular: 446.45
• Código UNSPSC: 51191904
• NACRES: NA.25

Propriedades

• Ensaio: >99% (TLC)
• Formulário: liquid
• embalagem: pkg of 1 × 1 mL (830842C-10mg); pkg of 1 × 2.5 mL (830842C-25mg)
• fabricante/nome comercial: Avanti Research^™ - A Croda Brand 830842C
• concentração: 10 mg/mL (830842C-10mg); 10 mg/mL (830842C-25mg)
• tipo de lipídio: cardiolipins; phospholipids
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• InChI: 1S/C19H37O8P.Na/c1-3-5-7-9-11-13-18(20)25-15-17(16-26-28(22,23)24)27-19(21)14-12-10-8-6-4-2;/h17H,3-16H2,1-2H3,(H2,22,23,24);/q;+1/p-1/t17-;/m1./s1
• chave InChI: ZNDNSOYDPUTHKQ-UNTBIKODSA-M

Descrição

Descrição geral

Phosphatidic acid (PA) is a diacyl-glycerophospholipid. Two fatty acids and a phosphate group are attached to a glycerol molecule with the help of covalent bond through ester linkage. PA can be synthesized by the activity of the endogenous enzyme phospholipase D. This prime glycerophospholipid is present in the biomembrane. 08:0 PA (1,2-dioctanoyl-sn-glycero-3-phosphate), a short chain PA is a cell-permeable analog of PA.

Aplicação

08:0 PA has been used to induce differentiation in order to study the effects of phosphatidic acids (PAs) on the inhibition of adipogenic differentiation in 3T3-L1 preadipocytes. It may be used as a mammalian target of rapamycin (mTOR) activator in SGC-996 gall bladder carcinoma cells. It may also be used to study its effects on intracellular Ca²⁺ concentration ([Ca²⁺]i) in C6 rat glioma and L2071 mouse fibroblast cells.

Ações bioquímicas/fisiológicas

Phosphatidic acid (PA) serves as a precursor for phosphatidylcholine or phosphatidylserine. It plays a functional role in influencing the membrane curvature and signaling. C8-PA/08:0 PA can block its association with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNAREs) to prevent the priming activity on isolated vacuoles. It also has the ability to change the proteolytic cleavage profile of Sec18.

Embalagem

5 mL Clear Glass Sealed Ampule (830842C-10mg)

5 mL Clear Glass Sealed Ampule (830842C-25mg)

Informações legais

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Informações de segurança

• Pictogramas: GHS06,GHS08
• Palavra indicadora: Danger
• Frases de perigo: H302,H315,H319,H331,H336,H351,H361d,H372,H412
• Declarações de precaução: P201 - P273 - P301 + P312 + P330 - P302 + P352 - P304 + P340 + P311 - P308 + P313
• Classificações de perigo: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
• Órgãos-alvo: Central nervous system, Liver,Kidney
• Classe de risco de água (WGK): WGK 3