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Documentos Principais

700172P

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cholesterol-d6

Avanti Research™ - A Croda Brand, powder

Sinônimo(s):

cholesterol-d6

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About This Item

Fórmula empírica (Notação de Hill):
C27H40D6O
Número CAS:
60816-17-3
Peso molecular:
392.69
Número MDL:
MFCD00201281
Código UNSPSC:
41141804
NACRES:
NA.25

Ensaio

>99% (TLC)

Formulário

powder

embalagem

pkg of 1 × 10 mg (700172P-10mg)

fabricante/nome comercial

Avanti Research™ - A Croda Brand

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

O[C@H]1CC[C@@]2([C@@H]3[C@H]([C@H]4[C@@]([C@H](CC4)[C@@H](CCCC(C([2H])([2H])[2H])C([2H])([2H])[2H])C)(CC3)C)CC=C2C1)C

chave InChI

HVYWMOMLDIMFJA-QSOBUISFSA-N

Descrição geral

Cholesterol-d6 is a deuterium labelled cholesterol. Ring labelled D6-cholesterol forms D6-steroidal glycoalkaloids (SGA).
Cholesterol-d6 is the deuterated cholesterol with deuteration in ring.

Aplicação

Cholesterol-d6 is suitable for its use as a synthetic lipid standard, for cholesterol determination.
Cholesterol-d6 is used as a standard to detect cholesterol concentration using chromatography technique. It is also used to measure the percentage of cholesterol absorption by intravenously administrating into experimental animals.
Cholesterol-d6 may be used as an internal standard in
  • electrospray ionization tandem mass spectrometry (ESIMS/MS)
  • gas chromatography–mass spectrometry (GC-MS)
  • for spiking lipid extracts from Drosophila for liquid chromatography–mass spectrometry (LC-MS)

Ações bioquímicas/fisiológicas

Cholesterol-d6 rich liposomes are used in understanding the kinetics of reverse cholesterol transport in lymphatic and aorta. It is used in the generation of stratum corneum (SC) lipid model systems for deuteration based neutron diffraction studies. Use of Cholesterol-d6 as a diet supplement has enabled the understanding cholesterol metabolism in the blood brain barrier.

Embalagem

5 mL Amber Glass Screw Cap Vial (700172P-10mg)

Informações legais

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 1

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Certificados de análise (COA)

Lot/Batch Number

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Biochemical membrane lipidomics during Drosophila development
Guan XL, et al.
Developmental Cell, 24(1), 98-111 (2013)
Perdeuteration of cholesterol for neutron scattering applications using recombinant Pichia pastoris
Moulin M, et al.
Chemistry and Physics of Lipids, 212, 80-87 (2018)
Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice
Martel C, et al.
The Journal of Clinical Investigation, 123(4), 1571-1579 (2013)
Cholesterol and Other Lipid Metabolism
Stable Isotope Characterization of TICs/TIMs: Analytical Progress Report. No. LLNL-TR-413939. Lawrence Livermore National Laboratory (LLNL), Livermore, CA, 2009., 157-157 (2003)
Localisation of partially deuterated cholesterol in quaternary SC lipid model membranes: a neutron diffraction study
Kessner D, et al.
European Biophysics Journal, 37(6), 1051-1057 (2008)
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