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927600

Sigma-Aldrich

BrBT-alkyne

≥95%

Sinônimo(s):

2-Bromo-N-(prop-2-yn-1-yl)benzo[d]thiazole-6-carboxamide

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About This Item

Fórmula empírica (Notação de Hill):
C11H7BrN2OS
Número CAS:
2550395-96-3
Peso molecular:
295.16
Número MDL:
MFCD34622465
Código UNSPSC:
12352101
NACRES:
NA.22

Nível de qualidade

100

Ensaio

≥95%

Formulário

powder

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

BrC1=NC2=CC=C(C(NCC#C)=O)C=C2S1

InChI

1S/C11H7BrN2OS/c1-2-5-13-10(15)7-3-4-8-9(6-7)16-11(12)14-8/h1,3-4,6H,5H2,(H,13,15)

chave InChI

MRYSQSUDZPBHGP-UHFFFAOYSA-N

Aplicação

BrBT-alkyne is a probe that can be used to lable cysteines through nucleophilic aromatic substitution. A method was developed using cysteine-reactive compounds including this one to allow for unbiased analysis of proteomic data in quantitave applications (Zanon et al. 2021). The method uses light or heavy labeling with the isotopically labelled desthiobiotin azide (isoDTB) tag for mass spectrometry analysis (Zanon et al. 2020). Analysis then uses the isotopic tandem orthogonal proteolysis activity-based protein profiling (isoTOP-ABPP) workflow (Weerapana et al. 2010, Backus et al. 2016).

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

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Isotopically Labeled Desthiobiotin Azide (isoDTB) Tags Enable Global Profiling of the Bacterial Cysteinome.
Zanon P R A, et al.
Angewandte Chemie (International Edition in English), 2829-2836 (2020)
Patrick R A Zanon et al.
Angewandte Chemie (International ed. in English), 59(7), 2829-2836 (2019-11-30)
Rapid development of bacterial resistance has led to an urgent need to find new druggable targets for antibiotics. In this context, residue-specific chemoproteomic approaches enable proteome-wide identification of binding sites for covalent inhibitors. Described here are easily synthesized isotopically labeled
Eranthie Weerapana et al.
Nature, 468(7325), 790-795 (2010-11-19)
Cysteine is the most intrinsically nucleophilic amino acid in proteins, where its reactivity is tuned to perform diverse biochemical functions. The absence of a consensus sequence that defines functional cysteines in proteins has hindered their discovery and characterization. Here we

Global Trade Item Number

SKUGTIN
927600-50MG4065268032183

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