804568

(R,S)-Bode Kinetic Resolution Catalyst

• Sinônimo(s): (4aR,9aS)-6-Bromo-4-hydroxy-4,4a,9,9a-tetrahydroindeno[2,1-b][1,4]oxazin-3(2H)-one
• Fórmula empírica (Notação de Hill): C₁₁H₁₀BrNO₃
• Número CAS: 1394957-71-1
• Peso molecular: 284.11
• Código UNSPSC: 12352101
• ID de substância PubChem: 329768882
• NACRES: NA.22

Propriedades

• forma: solution
• Nível de qualidade: 100
• grupo funcional: bromo; ether
• temperatura de armazenamento: 15-25°C
• cadeia de caracteres SMILES: O=C(CO1)N(O)[C@@]2([H])[C@]1([H])CC3=CC=C(Br)C=C32
• InChI: 1S/C11H10BrNO3/c12-7-2-1-6-3-9-11(8(6)4-7)13(15)10(14)5-16-9/h1-2,4,9,11,15H,3,5H2/t9-,11+/m0/s1
• chave InChI: FQXSUQCCAHKURK-GXSJLCMTSA-N

Descrição

Aplicação

The following hydroxamic acid catalyst was shown by Bode and coworkers to assist in the kinetic resolution of cyclic amines through acylation of one enantiomer, which can be controlled using either the (R or S)- or (S or R)-Bode Kinetic Resolution Catalyst, both of which are also available through Sigma-Aldrich.
It can also be employed in the preparation of nonracemic piperidines by kinetic resolution using an α-hydroxy-α′, β-unsaturated ketone in the presence of a pyrrolotriazolium salt.

Outras notas

Expanded substrate scope and catalyst optimization for the catalytic kinetic resolution of N-heterocycles

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302
• Declarações de precaução: P301 + P312 + P330
• Classificações de perigo: Acute Tox. 4 Oral
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable