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220957

Sigma-Aldrich

Tilorone dihydrochloride

95%

Sinônimo(s):

2,7-Bis[2-(diethylamino)ethoxy]-9-fluorenone dihydrochloride

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About This Item

Fórmula empírica (Notação de Hill):
C25H34N2O3 · 2HCl
Número CAS:
27591-69-1
Peso molecular:
483.47
Número MDL:
MFCD00134071
Código UNSPSC:
12352100
ID de substância PubChem:
24853201
NACRES:
NA.22

Nível de qualidade

100

Ensaio

95%

pf

230-233 °C (lit.)

cadeia de caracteres SMILES

Cl[H].Cl[H].CCN(CC)CCOc1ccc2-c3ccc(OCCN(CC)CC)cc3C(=O)c2c1

InChI

1S/C25H34N2O3.2ClH/c1-5-26(6-2)13-15-29-19-9-11-21-22-12-10-20(30-16-14-27(7-3)8-4)18-24(22)25(28)23(21)17-19;;/h9-12,17-18H,5-8,13-16H2,1-4H3;2*1H

chave InChI

BSVYJQAWONIOOU-UHFFFAOYSA-N

Categorias relacionadas

Descrição geral

Effect of tilorone dihydrochloride on the changes of transmembrane potential of mitochondrial membranes of the isolated rat hepatocytes has been investigated. Tilorone dihydrochloride is an orally active, interferon-inducing antiviral agent.

Aplicação

Tilorone dihydrochloride was used to study the interaction of drugs with synthetic self-complementary DNA by SPR (Surface Plasmon Resonance).

Pictogramas

Exclamation markHealth hazard
GHS07,GHS08

Palavra indicadora

Warning

Classificações de perigo

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

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Vladimir G Zinkovsky et al.
Pharmacological reports : PR, 59(6), 739-751 (2008-01-16)
Pharmacokinetics of amixin, a synthetic interferon inducer, has been studied in mice under intravenous and oral routes of administration. Following oral administration, 80% of the drug was eliminated in the unchanged form. Its absolute biological availability comprised 0.7. In comparison
N Ya Golovenko et al.
Bulletin of experimental biology and medicine, 140(6), 708-710 (2006-07-20)
Pharmacokinetics of amixin was studied after repeated administration (5 days) to animals. Perorally administered amixin is characterized by high bioavailability and is present in the circulation in high concentrations for a long time. The main pharmacokinetic parameters were estimated by
O V Dolga et al.
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 59(3), 31-38 (2013-08-21)
The early changes of electrophoretic mobility (EPM) of murine T lymphocytes induced by structural analogues of amixine-dihydrochloryde 4,4'-bis-[2(diethylamino)ethoxy]diphenyl (compound 1) and dihydrochloryde 2-methoxycarbonil-4,4'-bis-[2(diethylamino)ethoxy]diphenyl (compound 2) were studied by electrophoresis technique. During the interval 0-2 hours all compounds increased the absolute
H M Burke et al.
Journal of medicinal chemistry, 21(10), 1084-1086 (1978-10-01)
New synthetic routes to the orally active, interferon-inducing antiviral agent tilorone dihydrochloride, 2,7-bis-[(diethylamino)ethoxy]fluoren-9-one dihydrochloride (1a), were developed. The routes involved the preparation and solvolysis of tetrazonium fluoroborate salts of 2,7-diaminofluoren-9-one. Nonplanar (1b), 9-sulfone (1c), and fluorene (1d) analogues of tilorone
O I Skrots'ka et al.
Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993), 69(3), 62-68 (2007-08-09)
The authors studied the antiviral effect of an interferonogenic yeast RNA-tilorone molecular complex (MC) compared to the Virolex, videly used antiherpetic drug, and standard interferon (IFN) alpha/beta inducer poly(I)poly(C) in Vero cells culture infected with herpes simplex type I virus
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