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NOTCH3

notch 3

Sinônimos:
CADASIL, CASIL, IMF2
Espécies:
ID UniProtKB:
ID do gene:
  • Human(4854) Summary: This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008]
  • Mouse(18131) notch 3
  • Rat(56761) notch 3
  • Zebrafish(58066) notch homolog 3
  • dog(610439) notch 3
  • domestic cat(101088469) notch 3
  • cow(789485) notch 3
  • sheep(101123554) notch 3
  • domestic guinea pig(100716867) notch 3
  • naked mole-rat(101722220) notch 3

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ELISA

Número do produto
Descrição
Espécies
Human Notch-3 ELISA, for serum, plasma and cell culture supernatants,
Espécies
human

Antibodies

Número do produto
Descrição
Reatividade de espécies
Aplicação
Anti-NOTCH 3/N3ECD Antibody, clone 1E4, clone 1E4, 1 mg/mL, from mouse,
Reatividade de espécies
human
Aplicação
electron microscopy
immunocytochemistry

western blot
Monoclonal Anti-NOTCH3 antibody produced in mouse, clone 2E2, purified immunoglobulin, buffered aqueous solution,
Reatividade de espécies
human
Aplicação
ELISA
immunofluorescence

western blot
Anti-NOTCH3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reatividade de espécies
human
Aplicação
immunofluorescence
Anti-Notch 3 Antibody, clone 1G17 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reatividade de espécies
human, mouse, rat
Aplicação
affinity binding assay
immunocytochemistry

immunohistochemistry

western blot
Anti-NOTCH3 (C-terminal) antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Reatividade de espécies
human, mouse, rat
Aplicação
ELISA
immunohistochemistry

western blot

Small Molecule - Inhibitor

Número do produto
Descrição
Espécies
DAPT, ≥98% (HPLC), solid,
Espécies
mouse, human, rat
L-685,458, >96% (HPLC), solid,
Espécies
mouse, human, rat

esiRNA

Número do produto
Descrição
Espécies
MISSION® esiRNA, targeting mouse Notch3,
Espécies
mouse
MISSION® esiRNA, targeting human NOTCH3,
Espécies
human