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1335508

USP

Ibuprofen

United States Pharmacopeia (USP) Reference Standard

Synonyme(s) :

p-Isobutylhydratropic acid, Benzeneacetic acid, α-Methyl-4-(isobutyl)phenylacetic acid, (±)-2-(4-Isobutylphenyl)propanoic acid

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About This Item

Formule empirique (notation de Hill):
C13H18O2
Numéro CAS:
15687-27-1
Poids moléculaire :
206.28
Numéro MDL:
MFCD00010393
Code UNSPSC :
41116107
ID de substance PubChem :
329750144
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

ibuprofen

Fabricant/nom de marque

USP

Application(s)

pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

CC(C)Cc1ccc(cc1)C(C)C(O)=O

InChI

1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)

Clé InChI

HEFNNWSXXWATRW-UHFFFAOYSA-N

Informations sur le gène

human ... PTGS1(5742) , PTGS2(5743)

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Ibuprofen USP reference standard suitable for use in specified USP compendial tests and assays.

Also used to prepare standard preparation, standard and standard stock solution for performance tests, assay, identification, and impurity analysis according to the given below monographs of United States Pharmacopeia (USP):
  • Diphenhydramine Hydrochloride and Ibuprofen Capsules
  • Ibuprofen and Pseudoephedrine Hydrochloride Tablets

Actions biochimiques/physiologiques

Cyclooxygenase (COX) inhibitor that has greater activity against COX-1 than against COX-2.

Remarque sur l'analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

PHR1146

Ibuprofen Related Compound C, Pharmaceutical Secondary Standard; Certified Reference Material

1335541

Ibuprofen Related Compound C, United States Pharmacopeia (USP) Reference Standard

B1220000

Ibuprofen impurity B, European Pharmacopoeia (EP) Reference Standard

I0020000

Ibuprofen, European Pharmacopoeia (EP) Reference Standard

Y0000140

Ibuprofen impurity F, European Pharmacopoeia (EP) Reference Standard

Y0000881

Ibuprofen for peak identification, European Pharmacopoeia (EP) Reference Standard

61849

2-[4-(2-Methylpropyl)phenyl]ethanol, pharmaceutical impurity standard

1335596

Ibuprofen Related Compound J, United States Pharmacopeia (USP) Reference Standard

PHR1934

Ibuprofen Impurity B, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1964

Ibuprofen Impurity F, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1933

Impureté A d′ibuprofène, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1935

Ibuprofen Impurity N, Pharmaceutical Secondary Standard; Certified Reference Material

BP539

Ibuprofen, British Pharmacopoeia (BP) Reference Standard

BP557

4′-Isobutylacetophenone, British Pharmacopoeia (BP) Reference Standard

PHR2028

Ibuprofen Impurity H, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1965

Ibuprofen Impurity G, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2122

2-(4-Isobutyrylphenyl)propanamide, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2146

2-(4-Isobutylphenyl)-N-(1-phenylethyl)propionamide, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2141

2-(4-Isobutylphenyl)prop-2-enoic Acid, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2136

4-(1-Hydroxy-2-methylpropyl)-acetophenone, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2143

Ibuprofen 2,3-Butylene Glycol Ester, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2142

Ibuprofen 1,3-Butylene Glycol Esters, Pharmaceutical Secondary Standard; Certified Reference Material

BP880

Ibuprofen impurity B, British Pharmacopoeia (BP) Reference Standard

PHR2124

4-Isobutyrylacetophenone, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2145

Ibuprofen 1,2-Propanetriol Esters, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2144

Ibuprofen 1,2-Propylene Glycol Esters, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2483

4-Acetylbenzoic Acid, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2138

Ibuprofen Ethyl Ester

PHR2125

2-(4-Isobutyrylphenyl)propane

PHR2127

2-(4-n-Propylphenyl)propanoic Acid

PHR2129

Isopropyl 2-(4-Isobutylphenyl)propanoate

PHR2130

1-Ethyl-4-isobutylbenzene

PHR2134

4-Isobutylstyrene

PHR2135

1-(4-Isobutylphenyl)ethanol

PHR2132

2-[4-(2-Hydroxy-2-methylpropyl)-phenyl]propanoic Acid, certified reference material, pharmaceutical secondary standard

PHR2137

Ibuprofen Methyl Ester, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2133

Ibuprofen Intermediate, certified reference material, pharmaceutical secondary standard

PHR2126

2-Hydroxypropyl 2-(4-Isobutylphenyl)-propanoate, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2269

4-Isobutylbenzoic acid, Pharmaceutical Secondary Standard; Certified Reference Material

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302,H319,H335

Classification des risques

Acute Tox. 4 Oral - Eye Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

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Certificats d'analyse (COA)

Lot/Batch Number

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Supelco

I1892

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Acétaminophène United States Pharmacopeia (USP) Reference Standard

USP

1003009

Acétaminophène

Impureté A d’ibuprofène Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1933

Impureté A d′ibuprofène

Flurbiprofen United States Pharmacopeia (USP) Reference Standard

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1285750

Flurbiprofen

Captopril United States Pharmacopeia (USP) Reference Standard

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1091200

Captopril

(±)-Ibuprofen A nonsteroidal anti-inflammatory drug (NSAID) that acts as a reversible and competitive inhibitor of cyclooxygenase 1 (COX-1) (IC₅₀ = 4.85 µM).

Sigma-Aldrich

401003

(±)-Ibuprofen

(S)-(+)-Ibuprofen ReagentPlus®, 99%

Sigma-Aldrich

375160

(S)-(+)-Ibuprofen

Aspirin United States Pharmacopeia (USP) Reference Standard

USP

1044006

Aspirin

Aleem Adatia et al.
The Journal of pharmacy and pharmacology, 64(5), 626-636 (2012-04-05)
We review the pharmacological properties and clinical evidence pertaining to the efficacy of ibuprofen as a first-line treatment in hip and knee osteoarthritis (OA). In the context of our previous paper's exploration of the aetiology and pathogenesis of OA as
Roy Rabbie et al.
The Cochrane database of systematic reviews, 4(4), CD008039-CD008039 (2013-05-02)
This is an updated version of the original review published in Issue 10, 2010 (Rabbie 2010). Migraine is a common, disabling condition and a burden for the individual, health services and society. Many sufferers do not seek professional help, relying
Yexuan Mao et al.
Talanta, 132, 894-901 (2014-12-06)
The fundamental studies for the binding events of protein and its partner are crucial in drug development. In this study, a novel technology named microscale thermophoresis (MST) was applied in the investigation of molecular interaction between an organic dye fluorescein
Sheena Derry et al.
The Cochrane database of systematic reviews, 10(10), CD007550-CD007550 (2013-10-24)
This review is an update of a previously published review in The Cochrane Database of Systematic Reviews Issue 3, 2009 on single dose oral dexibuprofen (S(+)-ibuprofen) for acute postoperative pain in adults.Dexibuprofen is a non-steroidal anti-inflammatory drug (NSAID) licensed for
Roland Neumann et al.
Neonatology, 102(1), 9-15 (2012-03-15)
Pharmacological closure of patent ductus arteriosus (PDA) is commonly achieved by intravenous (IV) administration of ibuprofen or indomethacin. Occasionally, oral ibuprofen is used for PDA treatment although its efficacy and safety are unclear. To systematically review randomized and quasi-randomized trials
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