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I0020000

Ibuprofen

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

α-Methyl-4-(isobutyl)phenylacetic acid, (±)-2-(4-Isobutylphenyl)propanoic acid

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About This Item

Formule empirique (notation de Hill):
C13H18O2
Numéro CAS:
15687-27-1
Poids moléculaire :
206.28
Numéro MDL:
MFCD00010393
Code UNSPSC :
41116107
ID de substance PubChem :
329815293
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

ibuprofen

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

CC(C)Cc1ccc(cc1)C(C)C(O)=O

InChI

1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)

Clé InChI

HEFNNWSXXWATRW-UHFFFAOYSA-N

Informations sur le gène

human ... PTGS1(5742) , PTGS2(5743)

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Ibuprofen EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Actions biochimiques/physiologiques

Cyclooxygenase (COX) inhibitor that has greater activity against COX-1 than against COX-2.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

PHR1146

Ibuprofen Related Compound C, Pharmaceutical Secondary Standard; Certified Reference Material

1335508

Ibuprofen, United States Pharmacopeia (USP) Reference Standard

1335541

Ibuprofen Related Compound C, United States Pharmacopeia (USP) Reference Standard

B1220000

Ibuprofen impurity B, European Pharmacopoeia (EP) Reference Standard

Y0000140

Ibuprofen impurity F, European Pharmacopoeia (EP) Reference Standard

Y0000881

Ibuprofen for peak identification, European Pharmacopoeia (EP) Reference Standard

61849

2-[4-(2-Methylpropyl)phenyl]ethanol, pharmaceutical impurity standard

1335596

Ibuprofen Related Compound J, United States Pharmacopeia (USP) Reference Standard

PHR1934

Ibuprofen Impurity B, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1964

Ibuprofen Impurity F, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1933

Impureté A d′ibuprofène, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1935

Ibuprofen Impurity N, Pharmaceutical Secondary Standard; Certified Reference Material

BP539

Ibuprofen, British Pharmacopoeia (BP) Reference Standard

BP557

4′-Isobutylacetophenone, British Pharmacopoeia (BP) Reference Standard

PHR2028

Ibuprofen Impurity H, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1965

Ibuprofen Impurity G, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2122

2-(4-Isobutyrylphenyl)propanamide, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2146

2-(4-Isobutylphenyl)-N-(1-phenylethyl)propionamide, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2141

2-(4-Isobutylphenyl)prop-2-enoic Acid, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2136

4-(1-Hydroxy-2-methylpropyl)-acetophenone, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2143

Ibuprofen 2,3-Butylene Glycol Ester, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2142

Ibuprofen 1,3-Butylene Glycol Esters, Pharmaceutical Secondary Standard; Certified Reference Material

BP880

Ibuprofen impurity B, British Pharmacopoeia (BP) Reference Standard

PHR2124

4-Isobutyrylacetophenone, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2145

Ibuprofen 1,2-Propanetriol Esters, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2144

Ibuprofen 1,2-Propylene Glycol Esters, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2483

4-Acetylbenzoic Acid, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2138

Ibuprofen Ethyl Ester

PHR2125

2-(4-Isobutyrylphenyl)propane

PHR2127

2-(4-n-Propylphenyl)propanoic Acid

PHR2129

Isopropyl 2-(4-Isobutylphenyl)propanoate

PHR2130

1-Ethyl-4-isobutylbenzene

PHR2134

4-Isobutylstyrene

PHR2135

1-(4-Isobutylphenyl)ethanol

PHR2132

2-[4-(2-Hydroxy-2-methylpropyl)-phenyl]propanoic Acid, certified reference material, pharmaceutical secondary standard

PHR2137

Ibuprofen Methyl Ester, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2133

Ibuprofen Intermediate, certified reference material, pharmaceutical secondary standard

PHR2126

2-Hydroxypropyl 2-(4-Isobutylphenyl)-propanoate, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2269

4-Isobutylbenzoic acid, Pharmaceutical Secondary Standard; Certified Reference Material

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302,H319,H335

Classification des risques

Acute Tox. 4 Oral - Eye Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

Désolés, nous n'avons pas de COA pour ce produit disponible en ligne pour le moment.

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

R O Day et al.
Clinical pharmacology and therapeutics, 43(5), 480-487 (1988-05-01)
The simultaneous disposition of the enantiomers of ibuprofen in synovial fluid and plasma was studied in eight patients with arthritis. Concentrations of the active S-enantiomer in synovial fluid exceeded those of the R-enantiomer at all times in all patients with
Bart Van Overmeire et al.
Lancet (London, England), 364(9449), 1945-1949 (2004-11-30)
Ibuprofen is used for treatment and prevention of patent ductus arteriosus in low-birthweight infants. Its effects on regional circulations differ from those of indometacin. Because prophylactic indometacin reduces the frequency of severe intraventricular haemorrhage and patent ductus arteriosus, we aimed
J B Whitlam et al.
Clinical pharmacology and therapeutics, 29(4), 487-492 (1981-04-01)
Free and total ibuprofen levels in serum and synovial fluid (SF) were determined in one male and 14 female arthritic patients (mean age 56 yr, range 19 to 77) after 400 mg three times daily for 2 days. Free drug
Sheena Derry et al.
The Cochrane database of systematic reviews, 10(10), CD007550-CD007550 (2013-10-24)
This review is an update of a previously published review in The Cochrane Database of Systematic Reviews Issue 3, 2009 on single dose oral dexibuprofen (S(+)-ibuprofen) for acute postoperative pain in adults.Dexibuprofen is a non-steroidal anti-inflammatory drug (NSAID) licensed for
Carl Llor et al.
BMJ (Clinical research ed.), 347, f5762-f5762 (2013-10-08)
To evaluate the efficacy of oral anti-inflammatory or antibiotic treatment compared with placebo in the resolution of cough in patients with uncomplicated acute bronchitis and discoloured sputum. Multicentre, parallel, single blinded placebo controlled, randomised clinical trial. Nine primary care centres
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