T6764

Triprolidine hydrochloride

≥99%

• Synonyme(s) : (E)-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride, trans-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride
• Formule empirique (notation de Hill): C₁₉H₂₂N₂ · HCl
• Numéro CAS: 6138-79-0
• Poids moléculaire : 314.85
• Numéro MDL: MFCD00039044
• Code UNSPSC : 12352200
• ID de substance PubChem : 24277808
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥99%
• Solubilité: alcohol: soluble 1 in 1.5 of solvent; chloroform: soluble 1 in less than 1 of solvent; H₂O: soluble 50 mg/mL, clear, colorless to yellow
• Auteur: GlaxoSmithKline
• Température de stockage: 2-8°C
• Chaîne SMILES: CC(C=C1)=CC=C1/C(C2=NC=CC=C2)=C\CN3CCCC3.Cl
• InChI: 1S/C19H22N2.ClH/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21;/h2-3,6-12H,4-5,13-15H2,1H3;1H/b18-11+;
• Clé InChI: WYUYEJNGHIOFOC-NWBUNABESA-N
• Informations sur le gène: human ... HRH1(3269)

Description

Application

Triprolidine has been used as a H1 histaminergic inhibitor to study its effect on long-term potentiation (LTP) in tuberomammillary nucleus (TMN) neurons.

Actions biochimiques/physiologiques

H₁ histamine receptor antagonist.

Caractéristiques et avantages

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Notes préparatoires

Triprolidine hydrochloride is soluble in water at 50 mg/ml and yields a clear, colorless to yellow solution. It is also soluble in alcohol (1 in 1.5 of solvent) and chloroform (1 in less than 1 of solvent).

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302,H315,H319,H335
• Conseils de prudence: P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves