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T6319

Sigma-Aldrich

Anti-TOM22 antibody , Mouse monoclonal

clone 1C9-2, purified from hybridoma cell culture

Synonyme(s) :

Anti-Mitochondrial import receptor Tom22, Anti-TOMM22, Anti-Translocase of outer mitochondrial membrane 22 homolog (yeast)

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About This Item

Numéro MDL:
MFCD03457578
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

purified from hybridoma cell culture

Type de produit anticorps

primary antibodies

Clone

1C9-2, monoclonal

Forme

buffered aqueous solution

Poids mol.

antigen 22 kDa

Espèces réactives

human, monkey

Ne doit pas réagir avec

rodent

Concentration

~1 mg/mL

Technique(s)

immunocytochemistry: suitable
microarray: suitable
western blot: 0.5-1.0 μg/mL using whole extract of cultured human lymphoma Raji cells.

Isotype

IgG1

Numéro d'accès UniProt

Q9NS69

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... TOMM22(56993)

Description générale

Translocase of outer mitochondrial membrane 22 (TOMM22) is an essential receptor of the mitochondrial import channel. It is characterized with an N-terminal negatively charged region exposed to the cytosol, a putative transmembrane region and a C-terminal intermembrane space region with little negative charge.

Immunogène

membrane fraction from Vero (monkey kidney-derived) cells.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

  • Western blotting

Actions biochimiques/physiologiques

Translocase of outer mitochondrial membrane 22 (TOMM22) is a key constituent of TOM complex. It functions as a mitochondrial receptor for the proapoptotic protein Bax (BCL2-associated X protein). TOMM22 interacts with 3-β hydroxysteroid dehydrogenase 2 (3βHSD2) and converts pregnenolone-to-progesterone in steroidogenic cells.

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

TOM22, a core component of the mitochondria outer membrane protein translocation pore, is a mitochondrial receptor for the proapoptotic protein Bax.
Bellot G, et al.
Cell Death and Differentiation, 14(4), 785-785 (2007)
An outer mitochondrial translocase, Tom22, is crucial for inner mitochondrial steroidogenic regulation in adrenal and gonadal tissues.
Rajapaksha M, et al.
Molecular and Cellular Biology, 36(6), 1032-1047 (2016)
Andrey Aristov et al.
Nature communications, 9(1), 2409-2409 (2018-06-21)
Single molecule localization microscopy can generate 3D super-resolution images without scanning by leveraging the axial variations of normal or engineered point spread functions (PSF). Successful implementation of these approaches for extended axial ranges remains, however, challenging. We present Zernike Optimized Localization
Increased interaction between DJ-1 and the Mi-2/nucleosome remodelling and deacetylase complex during cellular stress.
Opsahl J A., et al.
Proteomics, 10(7), 1494-1504 (2010)
Anna-Maria Joseph et al.
PloS one, 8(7), e69327-e69327 (2013-08-13)
Mitochondrial DNA (mtDNA) mutations lead to decrements in mitochondrial function and accelerated rates of these mutations has been linked to skeletal muscle loss (sarcopenia). The purpose of this study was to investigate the effect of mtDNA mutations on mitochondrial quality
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