Accéder au contenu
Merck
Toutes les photos(3)

Documents

SAB3500459

Sigma-Aldrich

Anti-TOM70 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-TOMM70A, Anti-Translocase of the mitochondrial outer membrane 70

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(3)

About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

predicted mol wt 67 kDa

Espèces réactives

mouse, rat, human

Technique(s)

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

Numéro d'accès NCBI

NP_055635

Numéro d'accès UniProt

O94826

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... TOMM70A(9868)

Description générale

The Tom (translocase of the mitochondrial outer membrane) complex consists of two integral membrane import receptors, Tom20 and Tom70 (translocase of outer mitochondrial membrane 70) and a GIP (general import pore) complex. TOM70/ TOMM70A has 12 coding exons and spans about 37kb. It is abundantly expressed in human tissues and is located on human chromosome 3q13.1-q13.2. It belongs to the tetratricopeptide repeat (TPR) co-chaperone family. TOM70 has a dicarboxylate TPR clamp domain that can interact with molecular chaperones like Hsp70 (heat shock protein 70)/Hsc70 and/or Hsp90.

Immunogène

TOM70 antibody was raised against a 17 amino acid peptide near the amino terminus of human TOM70.

Actions biochimiques/physiologiques

TOM70/ TOMM70A (translocase of outer mitochondrial membrane 70) has the capability to identify preproteins with internal hydrophobic targeting sequences. It contributes in the transportation of several large hydrophobic matrix proteins. The import receptor Tom70 acts as a docking site for cytosolic multichaperone complexes.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Liaison

The action of this antibody can be blocked using blocking peptide SBP3500459.

Forme physique

Supplied in PBS with 0.02% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Outil de sélection de produits.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Human mitochondrial import receptor Tom70 functions as a monomer.
Fan AC, et al.
The Biochemical Journal, 429(3), 553-563 (2010)
Characterization of a human import component of the mitochondrial outer membrane, TOMM70A.
Edmonson AM, et al.
Cell communication & adhesion, 9(1), 15-27 (2002)
Anna C Y Fan et al.
The Journal of biological chemistry, 286(37), 32208-32219 (2011-07-21)
The mitochondrial import receptor Tom70 contains a tetratricopeptide repeat (TPR) clamp domain, which allows the receptor to interact with the molecular chaperones, Hsc70/Hsp70 and Hsp90. Preprotein recognition by Tom70, a critical step to initiate import, is dependent on these cytosolic
Sven Geisler et al.
Journal of cell science, 127(Pt 15), 3280-3293 (2014-06-08)
Depolarized mitochondria are degraded by mitophagy in a process that depends on the Parkinson's disease gene products PINK1 and Parkin. This is accompanied by ubiquitylation of several mitochondrial substrates. The roles of E2 ubiquitin-conjugating enzymes (UBE2) in mitophagy are poorly

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique