SML3623

DSRM-3716

≥98% (HPLC)

• Synonyme(s) : 5-Iodoisoquinoline, DSRM 3716, DSRM3716
• Formule empirique (notation de Hill): C₉H₆IN
• Numéro CAS: 58142-99-7
• Poids moléculaire : 255.06
• Numéro MDL: MFCD11226893
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: , yellow to light brown
• Solubilité: DMSO: 2 mg/mL, clear (Warmed)
• Température de stockage: 2-8°C

Description

Actions biochimiques/physiologiques

DSRM-3716 is a potent and selective SARM1 NADase inhibitor (NAD+ hydrolysis IC50 = 75 nM using recombinant SARM1 SAM-TIR construct) that recapitulates the SARM1-/- phenotype and protects axons from degeneration induced by axotomy (EC50 = 2.1/1.9 µM by fragmentation/NfL release using mouse DRG neurons; 81/88% protection by 1/3 µM DSRM-3716 using human iPSC-derived motor neurons) or mitochondrial dysfunction (3-30 µM DSRM-3716 against 25 µM rotenone-induced injury; mouse DRG neurons). Mechanistically, DSRM-3716 undergoes base exchange with the nicotinamide (NAM) moiety of nicotinamide adenine dinucleotide (NAD+) to yield the bona fide inhibitor 1AD.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H302,H311,H315,H319,H412
• Conseils de prudence: P264 - P273 - P280 - P301 + P312 - P302 + P352 + P312 - P305 + P351 + P338
• Classification des risques: Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Skin Irrit. 2
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable