SML1555

MS023 hydrochloride

≥98% (HPLC)

• Synonyme(s) : N1-((4-(4-Isopropoxyphenyl)-1H-pyrrol-3-yl)methyl)-N1-methylethane-1,2-diamine hydrochloride, N1-Methyl-N1-[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]-1,2-ethanediamine hydrochloride
• Formule empirique (notation de Hill): C₁₇H₂₅N₃O · xHCl
• Numéro CAS: 1831110-54-3
• Poids moléculaire : 287.40 (free base basis)
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825962
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white to light brown
• Solubilité: H₂O: 20 mg/mL, clear
• Température de stockage: −20°C
• Chaîne SMILES: CN(CCN)CC1=CNC=C1C2=CC=C(OC(C)C)C=C2.[H]Cl
• InChI: 1S/C17H25N3O.ClH/c1-13(2)21-16-6-4-14(5-7-16)17-11-19-10-15(17)12-20(3)9-8-18;/h4-7,10-11,13,19H,8-9,12,18H2,1-3H3;1H
• Clé InChI: IEZPALXFXHDDHI-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

MS023 is a potent and selective chemical probe for Type I protein arginine methyltransferases (PRMTs). MS023 is a potent inihbitor of PRMTs 1,3,4,6,and 8 (IC₅₀ = 30, 119, 83, 8, and 8 nM, respectively), which are responsible for asymmetric dimethylation of arginine residues. MS023 is active in cells. For full characterization details, please visit the MS023 probe summary on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

Caractéristiques et avantages

MS023 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Autres remarques

MS023 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the MS023 probe summary on the Chemical Probes Portal website.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable