SML1463

NHI-2

≥98% (HPLC)

• Synonyme(s) : 1-Hydroxy-6-phenyl-4-(trifluoromethyl)-1H-Indole-2-carboxylic acid methyl ester, Methyl 1-hydroxy-6-phenyl-4-(trifluoromethyl)-1H-indole-2-carboxylate
• Formule empirique (notation de Hill): C₁₇H₁₂F₃NO₃
• Numéro CAS: 1269802-97-2
• Poids moléculaire : 335.28
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825897
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 20 mg/mL, clear
• Température de stockage: 2-8°C
• Chaîne SMILES: ON(C(C(OC)=O)=C1)C2=C1C(C(F)(F)F)=CC(C3=CC=CC=C3)=C2
• InChI: 1S/C17H12F3NO3/c1-24-16(22)15-9-12-13(17(18,19)20)7-11(8-14(12)21(15)23)10-5-3-2-4-6-10/h2-9,23H,1H3
• Clé InChI: YPPFWRWCZNXINO-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

NHI-2 is an inihbitor of Lactate dehydrogenase-A (LDH-A, LDHA), a key enzyme necessary to sustain glycolysis, the major pathway used by many cancer cells for cell growth and proliferation (the Warburg effect). NHI-2 has anti-glycolytic activity against a variety of cancer cells. NHI-2 inhibited cell growth of pancreatic cancer LPC006 and PANC-1 cells and enhanced the antiproliferative effects of Gemcitabine and caused apoptosis in colon cancer HCT116 cells.

NHI-2 possesses highr cell permeability.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable