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347795

Sigma-Aldrich

Sodium dichloroacetate

98%

Synonyme(s) :

Dichloroacetic acid sodium salt

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About This Item

Formule linéaire :
Cl2CHCO2Na
Numéro CAS:
2156-56-1
Poids moléculaire :
150.92
Numéro CE :
218-461-3
Numéro MDL:
MFCD00070489
Code UNSPSC :
12352302
ID de substance PubChem :
24861527
Nomenclature NACRES :
NA.22

Pureté

98%

Impuretés

<2% ethyl alcohol

Pf

198 °C (dec.) (lit.)

Chaîne SMILES 

[Na+].[O-]C(=O)C(Cl)Cl

InChI

1S/C2H2Cl2O2.Na/c3-1(4)2(5)6;/h1H,(H,5,6);/q;+1/p-1

Clé InChI

LUPNKHXLFSSUGS-UHFFFAOYSA-M

Informations sur le gène

human ... PDK1(5163) , PDK2(5164) , PDK3(5165) , PDK4(5166)

Description générale

Sodium dichloroacetate is a mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor that exhibits potent anti-leukemic activity.

Application

Sodium dichloroacetate can be used as an organic salt precursor for synthesizing microporous carbon that is useful in developing carbon-based adsorbents.

Autres remarques

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Pictogrammes

Health hazardExclamation mark
GHS08,GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319,H335,H351

Classification des risques

Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

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Millipore

376817-M

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Methyl dichloroacetate &#8805;99%

Sigma-Aldrich

35840

Methyl dichloroacetate

Preparing microporous carbon from solid organic salt precursors using in situ templating and a fixed-bed reactor.
Atkinson JD & Rood MJ.
Microporous and Mesoporous Materials : The Official Journal of the International Zeolite Association, 160, 174-181 (2012)
Marie-Aline Neveu et al.
Oncotarget, 7(49), 81741-81749 (2017-01-14)
Reverting glycolytic metabolism is an attractive strategy for cancer therapy as upregulated glycolysis is a hallmark in various cancers. Dichloroacetate (DCA), long used to treat lactic acidosis in various pathologies, has emerged as a promising anti-cancer drug. By inhibiting the
Mito-DCA: a mitochondria targeted molecular scaffold for efficacious delivery of metabolic modulator dichloroacetate.
Pathak RK, et al.
ACS Chemical Biology, 9(5), 1178-1187 (2014)
Mario Ammendola et al.
Scientific reports, 10(1), 6521-6521 (2020-04-18)
The growing interest of oncologists in natural compounds such as polyphenols and flavonoids is encouraging the development of innovative and efficient carriers for the delivery of those drugs. This study examines carboxymethyl chitosan-based microcapsules created by spray drying as a
Han Shen et al.
Molecular cancer therapeutics, 14(8), 1794-1804 (2015-06-13)
Because radiotherapy significantly increases median survival in patients with glioblastoma, the modulation of radiation resistance is of significant interest. High glycolytic states of tumor cells are known to correlate strongly with radioresistance; thus, the concept of metabolic targeting needs to
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