SML0471

A22 hydrochloride

≥95% (HPLC)

• Synonyme(s) : MreB Perturbing Compound A22, S-(3,4-Dichlorobenzyl)isothiourea hydrochloride
• Formule empirique (notation de Hill): C₈H₈Cl₂N₂S · HCl
• Numéro CAS: 22816-60-0
• Poids moléculaire : 271.59
• Numéro MDL: MFCD00035050
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825427
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white to beige
• Solubilité: H₂O: 2 mg/mL (clear solution, warmed)
• Température de stockage: 2-8°C
• Chaîne SMILES: Cl.NC(=N)SCc1ccc(Cl)c(Cl)c1
• InChI: 1S/C8H8Cl2N2S.ClH/c9-6-2-1-5(3-7(6)10)4-13-8(11)12;/h1-3H,4H2,(H3,11,12);1H
• Clé InChI: VBJNMXMOMSWRDV-UHFFFAOYSA-N

Description

Application

A22 hydrochloride has been used to study its anti-biofilm activity, antibacterial, cyto and genotoxic activities. It is also used as a MreB polymerization inhibitor to understand the role of MreB polymers in Candidatus Thiosymbion oneisti and Candidatus T. hypermnestrae division.

Actions biochimiques/physiologiques

A22 is an inhibitor of MreB, an actin-like bacterial protein, and has been shown to act as an antiobiotic adjuvant. A22 inhibition of MreB disrupts the bacterial actin cytoskeleton, which can cause an increase in cell permeability and altered transport. A22 has been shown to have synergistic effects with several antibiotics including novobiocin and rifampin in gram negative bacteria.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable