SML0091

L-Dopa ethyl ester

≥98% (HPLC)

• Synonyme(s) : 3,4-Dihydroxy-L-phenylalanine ethyl ester, 3-Hydroxy-L-tyrosine ethyl ester, Etilevodopa, L-Dopa ethyl ester, L-Dopa-Et, Levodopa ethyl ester, O-Ethyl-DOPA, TV-1203
• Formule empirique (notation de Hill): C₁₁H₁₅NO₄
• Numéro CAS: 37178-37-3
• Poids moléculaire : 225.24
• Numéro MDL: MFCD00871210
• Code UNSPSC : 12352108
• ID de substance PubChem : 329825151
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Forme: powder
• Activité optique: [α]/D +15 to +19°, c = 1 in methanol ([α]/D)
• Couleur: white to tan
• Solubilité: H₂O: ≥12 mg/mL at warmed to 60 °C
• Température de stockage: 2-8°C
• Chaîne SMILES: CCOC(=O)[C@@H](N)Cc1ccc(O)c(O)c1
• InChI: 1S/C11H15NO4/c1-2-16-11(15)8(12)5-7-3-4-9(13)10(14)6-7/h3-4,6,8,13-14H,2,5,12H2,1H3/t8-/m0/s1
• Clé InChI: NULMGOSOSZBEQL-QMMMGPOBSA-N
• Informations sur le gène: human ... DRD3(1814)

Description

Application

L-Dopa ethyl ester has been used to study the protective effects of piperlongumine (PLG) on rotenone-induced Parkinson disease (PD).

Actions biochimiques/physiologiques

L-Dopa ethyl ester (L-Dopa) is a dopamine replacement drug. It is used as a potent therapeutic for Parkinson disease (PD). L-Dopa has some long-term side effects, such as the deterioration of motor function.

L-Dopa ethyl ester is a prodrug of levodopa that has greater gastric solubility. The drug is rapidly hydrolyzed to levodopa by nonspecific esterases in the gastrointestinal tract. L-Dopa ethyl ester (etilevodopa)-carbidopa treatment was well tolerated but did not demonstrate better efficacy compared with standard levodopa-carbidopa treatment. L-Dopa ethyl ester should have a significant brain penetration following an administration by injection.

Caractéristiques et avantages

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302,H319
• Conseils de prudence: P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
• Classification des risques: Acute Tox. 4 Oral - Eye Irrit. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable