SMB01078

Inulicin

≥90% (LC/MS-ELSD)

• Synonyme(s) : 1-O-Acetylbritannilactone, Britannilactone 1-O-acetate
• Formule empirique (notation de Hill) : C₁₇H₂₄O₅
• Numéro CAS: 33627-41-7
• Poids moléculaire : 308.37
• Numéro MDL: MFCD30207877
• Code UNSPSC : 12352205
• Nomenclature NACRES : NA.25

Propriétés

• Source biologique: plant
• Essai: ≥90% (LC/MS-ELSD)
• Forme: solid
• Poids mol.: 308.37
• Application(s): metabolomics; vitamins, nutraceuticals, and natural products
• Température de stockage: −20°C
• Chaîne SMILES: O1[C@H]2[C@H]([C@@H](C(=C(C2)C)[C@H](CCCOC(=O)C)C)O)C(=C)C1=O
• InChI: 1S/C17H24O5/c1-9(6-5-7-21-12(4)18)14-10(2)8-13-15(16(14)19)11(3)17(20)22-13/h9,13,15-16,19H,3,5-8H2,1-2,4H3/t9-,13+,15+,16+/m0/s1
• Clé InChI: QKUFZFLZBUSEHN-CZLJMHDISA-N

Description

Description générale

Inulicin, a sesquiterpene lactone, is a natural bioactive compound commonly sourced from plants like Pentanema britannicum and Inula japonica. Current research indicates that this plant-derived metabolite may possess inhibitory properties, showcasing a range of biological activities, including anti-inflammatory, cardioprotective, antiangiogenic, and anticancer activities.

Application

Inulicin is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

Actions biochimiques/physiologiques

Inulicin exhibits anticancer properties by inhibiting angiogenesis and lung cancer cell proliferation, potentially through the regulation of VEGFR-Src-FAK signaling. When combined with gemcitabine, it promotes strong apoptosis in lung cancer cells. Additionally, Inulicin shows promise in the treatment of various cardiovascular diseases, including chronic ischemia, by modulating VEGF signaling and angiogenesis. It also serves as a potent inhibitor of LPS-induced inflammatory responses in vascular smooth muscle cells, acting through the blockade of NF-kappaB activity and the suppression of the inflammatory gene COX-2. Furthermore, Inulicin displays potential as a natural skin-lightening agent, reducing melanogenesis by suppressing tyrosinase expression via ERK and Akt signaling pathways.

Caractéristiques et avantages

• Suitable for Biochemical and Biomedical research
• Versatile and adaptable for wide variety of laboratory and research applications

Autres remarques

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Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P264 - P270 - P301 + P312 - P501
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable