S1542
Anti-Substance P antibody produced in rabbit
whole antiserum
Synonyme(s) :
Anti-SP
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About This Item
Produits recommandés
Source biologique
rabbit
Niveau de qualité
Conjugué
unconjugated
Forme d'anticorps
whole antiserum
Type de produit anticorps
primary antibodies
Clone
polyclonal
Contient
15 mM sodium azide
Espèces réactives
human, pig, bovine, rat, cat, monkey
Technique(s)
dot blot: 1:20,000
radioimmunoassay: 1:5,000
Numéro d'accès UniProt
Conditions d'expédition
dry ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... TAC1(6863)
rat ... Tac1(24806)
Description générale
Substance P (SP) is a 11 amino acid peptide. It is a member of tachykinins family, that includes neurokinin A, neurokinin B, neuropeptide K, neuropeptide Y and hemokinin-1 It is located on human chromosome 7q21.3.
Substance P (SP) is widely distributed throughout the central nervous system (CNS) and peripheral nervous system, including the brain, spinal cord, primary sensory neurons and intrinsic nerve fibers associated with the gastrointestinal (GI) tract.
Immunogène
synthetic Substance P (SP), conugated to KLH.
Application
Anti-Substance P antibody has been used in immunostaining and immunohistochemistry.
Actions biochimiques/physiologiques
Substance P (SP) improves the multiplication and paracrine ability of stem cells acquired from adipose in vitro. It participates in the movement of several organ tracts, trigger glandular secretion and controls autonomic reflexes. It plays an important role in neuroimmune and systemic autoimmune/inflammatory conditions like multiple sclerosis (MS), rheumatoid arthritis, inflammatory bowel disease and also in infections and cancer.
Substance P (SP) is a neurotransmitter or neuromodulator. SP mediates the process of neurogenic inflammation.
Remarque sur l'analyse
The antiserum is evaluated for activity and specificity by dot blot immunoassay and RIA.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Inge Brouns et al.
American journal of respiratory cell and molecular biology, 28(3), 275-285 (2003-02-21)
The characteristics of the different populations of sensory nerve terminals that selectively contact pulmonary neuroepithelial bodies (NEBs) in rat lungs were investigated after chemical denervation with capsaicin and compared with control lungs. Vagal calbindin D28k and P2X(3) purinoceptor immunoreactive (IR)
Reciprocal Regulation of Substance P and IL-12/IL-23 and the Associated Cytokines, IFN?/IL-17: A Perspective on the Relevance of This Interaction to Multiple Sclerosis
Vilisaar J, et al.
Journal of Neuroimmune Pharmacology, 10(3), 457-467 (2015)
Xi Zhang et al.
Brain and behavior, 11(11), e2380-e2380 (2021-09-29)
FSC231, a PSD-95/DLG/ZO-1 (PDZ) domain inhibitor of protein kinase Cα interacting protein 1 (PICK1), has analgesic effects, but the mechanism remains unclear. The expression level of PICK1 in dorsal root ganglion (DRG) of rats was changed by vector plasmid, and
Substance P mediates inflammatory oedema in acute pancreatitis via activation of the neurokinin-1 receptor in rats and mice
Grady EF, et al.
British Journal of Pharmacology, 130(3), 505-512 (2000)
Substance P enhances proliferation and paracrine potential of adipose-derived stem cells in vitro
Kim S, et al.
Biochemical and Biophysical Research Communications, 485(1), 131-113 (2017)
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