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COO/COA

PRS3985

Anti-Nicastrin (ab2) antibody produced in rabbit

Name: Anti-Nicastrin (ab2) antibody produced in rabbit
Brand: SIGMA

affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-APH-2, Anti-Anterior pharynx defective 2, Anti-Nicastrin

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About This Item

Numéro MDL:

MFCD03791914

Code UNSPSC :

12352203

Nomenclature NACRES :

NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Espèces réactives

human, rat, mouse

Technique(s)

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

Numéro d'accès UniProt

Q92542

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... NCSTN(23385)

Description générale

Nicastrin (NCSTN) is a transmembrane glycoprotein, that is located on chromosome 1q23.

Immunogène

a 18 amino acid peptide from near the center of human Nicastrin.

Application

Anti-Nicastrin has been used in western blotting.

Actions biochimiques/physiologiques

Nicastrin (NCSTN) helps in the assembly of γ-secretase complex. It is associated with Alzheimer′s disease.

Liaison

The action of this antibody can be blocked using blocking peptide SBP3985.

Forme physique

Solution in phosphate buffered saline containing 0.02% sodium azide

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta

Kuzuya A, et al.

BMC Biology, 14:25 (2016)

The gene encoding nicastrin, a major gamma-secretase component, modifies risk for familial early-onset Alzheimer disease in a Dutch population-based sample

Dermaut B, et al.

American Journal of Human Genetics, 70(6), 1568-1574 (2002)

Functional Variants in Notch Pathway Genes NCOR2, NCSTN, and MAML2 Predict Survival of Patients with Cutaneous Melanoma

Zhang W, et al.

Cancer Epidemiology, Biomarkers & Prevention (2015)

Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta.

Akira Kuzuya et al.

BMC biology, 14, 25-25 (2016-04-03)

Synaptic loss strongly correlates with memory deterioration. Local accumulation of amyloid β (Aβ) peptide, and neurotoxic Aβ42 in particular, due to abnormal neuronal activity may underlie synaptic dysfunction, neurodegeneration, and memory impairments. To gain an insight into molecular events underlying

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