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P2850

Sigma-Aldrich

Phosphatase Inhibitor Cocktail 1

DMSO solution, mixture of inhibitors

Synonyme(s) :

Phosphatase Inhibitor

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About This Item

Numéro CE :
200-664-3
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.54

product name

Phosphatase Inhibitor Cocktail 1, DMSO solution

Forme

DMSO solution

Niveau de qualité

300

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Description générale

Phosphatase Inhibitor Cocktail 1 includes a mixture of inhibitors that will inhibit the L-isozymes of alkaline phosphatase as well as serine/threonine protein phosphatases such as PP1 and PP2A. This product contains microcystinLR, cantharidin, and (−)-p-bromotetramisole. Phosphatase Inhibitor Cocktail 1 has been replaced with P0044.

Application

Phosphatase Inhibitor Cocktail 1 has been used in nuclear protein isolation and electrophoretic mobility shift assay (EMSA) for catenin activation. It has also been used in western blot analysis.

Actions biochimiques/physiologiques

Phosphatases are active regulators of a number of important biological processes. Inhibition of phosphatases by small molecules is useful to study its biological role.

Quantité

Recommended usage is a 100-fold dilution.

Remarque sur l'analyse

Tested on cell extracts from animal tissues such as bovine liver, human placenta, and rabbit muscle, as well as on extracts from A431 and Jurkat cell lines.

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

188.6 °F

Point d'éclair (°C)

87 °C

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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X Zhao et al.
Mucosal immunology, 10(6), 1553-1568 (2017-04-13)
Virulent Mycobacterium tuberculosis (Mtb) triggers necrosis in host Mϕ, which is essential for successful pathogenesis in tuberculosis. Here we demonstrate that necrosis of Mtb-infected Mϕ is dependent on the action of the cytosolic Receptor Interacting Protein Kinase 3 (RIPK3) and
Aberrant Wnt/β-catenin signaling in pancreatic adenocarcinoma.
Zeng G, et al.
Neoplasia, 8(4), 279-289 (2006)
Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis.
Noren M A, et al.
Proceedings of the National Academy of Sciences of the USA, 103(28), 10606-10611 (2006)
Larger therapeutic window for steroid versus VEGF-A inhibitor in inflammatory angiogenesis: surprisingly similar impact on leukocyte infiltration.
Nakao S, et al.
Investigative Ophthalmology & Visual Science, 53(7), 3296-3302 (2012)
Nicolas Manel et al.
Nature, 467(7312), 214-217 (2010-09-11)
Dendritic cells serve a key function in host defence, linking innate detection of microbes to activation of pathogen-specific adaptive immune responses. Whether there is cell-intrinsic recognition of human immunodeficiency virus (HIV) by host innate pattern-recognition receptors and subsequent coupling to
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Phosphatase Inhibitor Cocktail

Information on Phosphatase Inhibitor Cocktail for researchers and students from MilliporeSigma. Phosphorylation is a reversible protein post-translational modification.

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

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