L4129
L-α-Lysophosphatidylcholine from egg yolk
≥99%, Type I, powder
Synonyme(s) :
1-Acyl-sn-glycero-3-phosphocholine, L-α-Lysolecithin
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About This Item
Numéro CAS:
Numéro CE :
Numéro MDL:
Code UNSPSC :
12352211
Nomenclature NACRES :
NA.25
Produits recommandés
Source biologique
egg yolk
Niveau de qualité
Description
zwitterionic
Type
Type I
Essai
≥99%
Forme
powder
Couleur
white
Groupe fonctionnel
phospholipid
Type de lipide
phosphoglycerides
Conditions d'expédition
ambient
Température de stockage
−20°C
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Application
L-α-Lysophosphatidylcholine from egg yolk has been used:
- as a surfactant
- as a media supplement and in Staphylococcus aureus inhibition assay in dermatitis
- as a demyelinating agent for nerve
- as a component in sperm nuclei preparation buffer
Actions biochimiques/physiologiques
Lysophosphatidylcholine is a major component of oxidized low density lipoproteins, and has been implicated in various inflammatory reactions, including atherosclerosis. It is used to demyelinate spinal neurons and study the processes underlying remyelination. It activates protein kinase C, p38 MAP kinase, p42 MAP Kinase, and the jun kinase (JNK) pathway, and stimulates transcription of c-jun. Lysophosphatidylcholine accumulates during cardiac ischemia and may induce arrhythmias by uncoupling gap junction communication, and increase ischemic damage by enhancing Na+ loading in cardiac myocytes. It also activates TREK1, TREK2 and TRAAK K+ channels.
Qualité
Contains primarily palmitic and stearic acids.
Notes préparatoires
Prepared by the action of phospholipase A on egg L-α-phosphatidylcholine.
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type N95 (US)
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Les clients ont également consulté
Christopher E McMurran et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(50), 25311-25321 (2019-11-20)
The microbiota is now recognized as a key influence on the host immune response in the central nervous system (CNS). As such, there has been some progress toward therapies that modulate the microbiota with the aim of limiting immune-mediated demyelination
Lauri J Lehto et al.
Frontiers in neuroscience, 11, 433-433 (2017-08-22)
In this work a new MRI modality entitled Relaxation Along a Fictitious Field in the rotating frame of rank 4 (RAFF4) was evaluated in its ability to detect lower myelin content in lysophosphatidyl choline (LPC)-induced demyelinating lesions. The lesions were
Isolation and demembranation of Xenopus sperm nuclei
Hazel JW and Gatlin JC
Cold Spring Harbor Protocols (2018)
RP-CARS: label-free optical readout of the myelin intrinsic healthiness
de Vito G, et al.
Optics Express, 22(11), 13733-13743 (2014)
Transplantation of human skin microbiota in models of atopic dermatitis
Myles IA, et al.
JCI insight, 1(10), 031712-031712 (2016)
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