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I4657

Sigma-Aldrich

Insulin-like Growth Factor-I Receptor human

≥95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Synonyme(s) :

IGF-I Receptor

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About This Item

Numéro MDL:
MFCD01323726
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.32

Source biologique

human

Niveau de qualité

200

Produit recombinant

expressed in NSO cells

Pureté

≥95% (SDS-PAGE)

Forme

lyophilized powder

Poids mol.

α-chain ~120 & 150 kDa
β subunit ~46 & 50 kDa

Conditionnement

pkg of 50 μg

Impuretés

endotoxin, tested

Numéro d'accès UniProt

P08069

Température de stockage

−20°C

Informations sur le gène

human ... IGF1R(3480)

Catégories apparentées

Description générale

IGF1R (insulin-like growth factor I) is a receptor tyrosine kinase. The gene is mapped to human chromosome 15q26. It is expressed in various solid tumors as well as hematologic malignancies.

Application

Insulin-like growth factor-I receptor human has been used to study the binding constants of estradiol to insulin, insulin receptors and insulin-like peptides.

Actions biochimiques/physiologiques

IGF-I receptor, a tyrosine kinase receptor with signal transduction pathways, is comprised of two α and two β subunits. IGF-I receptor binds IGF-I with high affinity, IGF-II with lower affinity, and insulin with weak affinity.

Forme physique

Lyophilized from a 0.2 μm solution in phosphate buffered saline.

Remarque sur l'analyse

As a result of glycosylation in SDS-PAGE under reducing conditions, the recombinant α subunit migrates as a doublet of ~120 kDa and 150 kDa and the β subunit migrates as doublet of ~46 kDa and 50 kDa.
The biological activity is measured by its ability to bind human IGF­-­I in a functional ELISA assay.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Sandra Heskamp et al.
PloS one, 10(2), e0117745-e0117745 (2015-02-14)
The insulin-like growth factor 1 receptor (IGF-1R) may be involved in the development of resistance against conventional cancer treatment. The aim of this study was to assess whether IGF-1R expression of breast tumors changes during neoadjuvant therapy and to study
Xin Huang et al.
PloS one, 10(7), e0133152-e0133152 (2015-07-15)
Patients with metastatic or recurrent and refractory sarcomas have a dismal prognosis. Therefore, new targeted therapies are urgently needed. This study was designed to evaluate chimeric antigen receptor (CAR) T cells targeting the type I insulin-like growth factor receptor (IGF1R)
Jin-Ho Choi et al.
The Journal of clinical endocrinology and metabolism, 96(1), E130-E134 (2010-10-22)
Mutations in the IGF1R gene result in intrauterine growth retardation and postnatal growth failure. The objective of this study was to describe the clinical features of subjects with a mutation in the IGF1R gene and to evaluate the molecular and
Robert Root-Bernstein et al.
Frontiers in endocrinology, 5, 118-118 (2014-08-08)
Insulin (INS) resistance associated with hyperestrogenemias occurs in gestational diabetes mellitus, polycystic ovary syndrome, ovarian hyperstimulation syndrome, estrogen therapies, metabolic syndrome, and obesity. The mechanism by which INS and estrogen interact is unknown. We hypothesize that estrogen binds directly to

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