Accéder au contenu
Merck
Toutes les photos(1)

Key Documents

View All Documentation

I2526

Sigma-Aldrich

Insulin-like Growth Factor-II human

≥98% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonyme(s) :

IGF-II

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(1)

About This Item

Numéro MDL:
MFCD00241895
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.77

product name

Insulin-like Growth Factor-II human, IGF-II, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Source biologique

human

Niveau de qualité

200

Produit recombinant

expressed in E. coli

Pureté

≥98% (SDS-PAGE and HPLC)

Forme

lyophilized powder

Puissance

≤2.0 ng/mL ED50

Qualité

endotoxin tested

Poids mol.

7.5 kDa

Conditionnement

pkg of 5X50 μg
pkg of 50 μg

Technique(s)

cell culture | mammalian: suitable

Impuretés

≤0.1 EU/μg

Numéro d'accès UniProt

P01344

Température de stockage

−20°C

Informations sur le gène

human ... IGF2(3481)

Vous recherchez des produits similaires ? Visite Guide de comparaison des produits

Catégories apparentées

Actions biochimiques/physiologiques

Insulin-like growth factor II (IGF-II) also known as multiplication stimulating activity (MSA), shows virtually identical bioactivities as IGF-I. Expression of IGF-II is highest in fetal tissues, where it is believed to play a major role in overall growth and development. After birth IGF-II expression decreases to much lower levels in a variety of tissues. IGF-II is produced also in several tumors. IGF-II binds to IGF-II receptor (IGF-IIR), to IGF-IR and weakly to the insulin receptor (IR). All IGF-II bioactivities in adult tissues are generally attributed to its interaction with IGF-IR. However, during embryogenesis the roles of both IGF-IIR and IR may be significant in promoting normal growth.

Forme physique

Lyophilized from a 0.2 μm filtered solution with no additives.

Remarque sur l'analyse

The biological activity is measured by a cell proliferation assay using mouse FDC-P1

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Les clients ont également consulté

Slide 1 of 5

1 of 5

Serum from rat

Sigma-Aldrich

R9759

Serum from rat

Insuline human recombinant, expressed in yeast (proprietary host)

Sigma-Aldrich

I2643

Insuline human

Sigma-Aldrich

Sigma-Aldrich

I3536

Insuline human

Insuline, humaine recombinante for research or for further manufacturing use, dry powder

SAFC

91077C

Insuline, humaine recombinante

Sigma-Aldrich

Sigma-Aldrich

I9278

Insuline solution human

Yongming Yuan et al.
Scientific reports, 7(1), 78-78 (2017-03-03)
Insulin-like growth factors (IGFs) regulate diverse processes including energy metabolism, cell proliferation and embryonic development. They activate the IGF signaling pathway via binding to cell surface receptors. Here we report an essential role of IGF2 in maintaining the pluripotency of
Jasmin Svinka et al.
Journal of molecular medicine (Berlin, Germany), 95(1), 109-117 (2016-08-29)
We have demonstrated that the signal transducer and activator of transcription 3 (STAT3) protects from cholestatic liver injury. Specific ablation of STAT3 in hepatocytes and cholangiocytes (STAT3∆hc) aggravated liver damage and fibrosis in the Mdr2-/- (multidrug resistance 2) mouse model
Till Seime et al.
Cells, 10(6) (2021-06-03)
Calcification is a prominent feature of late-stage atherosclerosis, but the mechanisms driving this process are unclear. Using a biobank of carotid endarterectomies, we recently showed that Proteoglycan 4 (PRG4) is a key molecular signature of calcified plaques, expressed in smooth
Chun-Chang Yeh et al.
International journal of molecular sciences, 16(11), 27156-27170 (2015-11-19)
Pulsed radiofrequency (PRF) is effective in the treatment of neuropathic pain in clinical practice. Its application to sites proximal to nerve injury can inhibit the activity of extra-cellular signal-regulated kinase (ERK) for up to 28 days. The spared nerve injury

Articles

Insulin-like Growth Factors (IGF)

Insulin-like Growth Factors (IGF)

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique