Toutes les photos(1)

Principaux documents

Voir toute la documentation

H6649

Herbimycin A from Streptomyces hygroscopicus

Name: Herbimycin A from <I>Streptomyces hygroscopicus</I>
Brand: SIGMA

≥95% (HPLC), powder

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme

Toutes les photos(1)

About This Item

Formule empirique (notation de Hill):

C₃₀H₄₂N₂O₉

Numéro CAS:

70563-58-5

Poids moléculaire :

574.66

Numéro Beilstein :

4834067

Numéro MDL:

MFCD00151702

Code UNSPSC :

12352200

ID de substance PubChem :

24895756

Nomenclature NACRES :

NA.77

Produits recommandés

Slide 1 of 1

1 of 1

Sigma-Aldrich

A7699

Adénosine 5′-triphosphate disodium salt hydrate

Source biologique

Streptomyces hygroscopicus

Niveau de qualité

200

Pureté

≥95% (HPLC)

Forme

powder

Couleur

yellow

Solubilité

DMSO: 7.5 mg/mL

Spectre d'activité de l'antibiotique

viruses

Mode d’action

enzyme | inhibits

Température de stockage

−20°C

Chaîne SMILES

CO[C@H]1C[C@H](C)[C@@H](OC)C2=CC(=O)C=C(NC(=O)\C(C)=C\C=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1OC)C2=O

InChI

1S/C30H42N2O9/c1-16-10-9-11-23(37-5)28(41-30(31)36)18(3)12-17(2)27(40-8)24(38-6)13-19(4)26(39-7)21-14-20(33)15-22(25(21)34)32-29(16)35/h9-12,14-15,17,19,23-24,26-28H,13H2,1-8H3,(H2,31,36)(H,32,35)/b11-9-,16-10+,18-12+/t17-,19-,23-,24-,26+,27+,28-/m0/s1

Clé InChI

MCAHMSDENAOJFZ-BVXDHVRPSA-N

Vous recherchez des produits similaires ? Visite Guide de comparaison des produits

Description générale

DMSO stock solution can be diluted in phosphate buffered saline. The ratio of buffer:DMSO should be greater than 500:1.

Herbimycin A from Streptomyces hygroscopicus is a benzoquinoid ansamycin antibiotic. It is an analog of geldanamycin.

Application

Herbimycin A from Streptomyces hygroscopicus has been used as an inhibitor of Src tyrosine kinase in HEK293T cells and rat intestinal epithelial cells. It has also been used to test its attenuation effect in intimal hyperplasia (IH) post balloon injury in rat carotid artery.

Actions biochimiques/physiologiques

Herbimycin A is an inducer of heat shock protein (HSP). It increases HSP expression resulting in the attenuation of ischemia reperfusion induced pulmonary injury.

An antibiotic that inhibits protein tyrosine kinase. Herbimycin A is a potent inhibitor of angiogenesis.

Attention

Hygroscopic and photosensitive

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Herbimycin A inhibits both dephosphorylation and translocation of cofilin induced by opsonized zymosan in macrophagelike U937 cells.

K Nagaishi et al.

Journal of cellular physiology, 180(3), 345-354 (1999-08-03)

We previously reported that a 21-kDa phosphoprotein may play an important role in superoxide production through dephosphorylation by neutrophillike differentiated HL-60 cells (Suzuki et al., 1995, Biochim Biophys Acta 1266: 261-267). The phosphoprotein was identified as cofilin, an actin-binding protein

Tyrosine kinase inhibitors block the glucocorticoid stimulation of prostaglandin endoperoxide H synthase expression in amnion cells.

T Zakar et al.

Canadian journal of physiology and pharmacology, 77(2), 138-142 (1999-10-27)

Human amnion cells in primary culture respond to glucocorticoids in a characteristic fashion by the increased expression of the inducible prostaglandin endoperoxide H synthase isoenzyme, PGHS-2. Since PGHS-2 induction by agonists generally involves tyrosine kinases, we examined the possibility that

Herbimycin A and geldanamycin inhibit okadaic acid-induced apoptosis and p38 activation in NRK-52E renal epithelial cells.

M A Davis et al.

Toxicology and applied pharmacology, 161(1), 59-74 (1999-11-24)

It is important to understand the mechanisms by which phosphorylation-dependent events play a role in regulation of apoptosis in toxicant-metabolizing organs such as the kidney. Our previous work demonstrated that the toxicant and phosphatase inhibitor okadaic acid induces apoptosis of

Tumor necrosis factor alpha stimulates invasion of Src-activated intestinal cells.

Naoki Kawai et al.

Gastroenterology, 122(2), 331-339 (2002-02-08)

Src activation is correlated with progression of colorectal cancer (CRC). CRCs accompanied by ulcerative colitis, chronic inflammation in the colon, often have elevated Src activity, and ulcerative colitis-related CRCs are more likely to become invasive, whereas Ras activation is rarely

Possible functional groups responsible for inhibition of in vivo angiogenesis by herbimycin A.

T Oikawa et al.

Biological & pharmaceutical bulletin, 17(10), 1430-1432 (1994-10-01)

Six herbimycin A (HBM) derivatives were examined for their anti-angiogenic effects in a bioassay system involving chorioallantoic membranes (CAMs) of growing chick embryos on the basis of our previous observation that HBM is a potent angiogenesis inhibitor. 17-Cyclopropylamino-HBM dose-dependently inhibited

Afficher tous les articles scientifiques apparentés

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique