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GW21229

Sigma-Aldrich

Anti-CLIF antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-Cycle-like factor CLIF

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

chicken

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Espèces réactives

human

Fabricant/nom de marque

Genway 15-288-21229

Technique(s)

western blot: suitable

Numéro d'accès NCBI

NP_064568.1

Numéro d'accès UniProt

Q9H2M4

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... CLIF(56938)

Immunogène

Immunogen Sequence: GI # 9910368, sequence 8-100
Recombinant transcription factor BMAL2

Application

Anti-CLIF antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Actions biochimiques/physiologiques

The CLIF gene encodes a member of the basic helix-loop-helix PER-ARNT-SIM family of transcription factors and is located on chromosome12. It helps in controlling diverse physiological processes including circadian rhythm. CLIF is expressed in endothelial cells and neurons in the brain, including the suprachiasmatic nucleus and the center of the circadian clock. In endothelial cells, it forms a heterodimer with CLOCK and up-regulates the PAI-1 gene through E-box sites. CLIF helps in regulating the circadian oscillation of PAI-1 gene expression in endothelial cells. Its expression is increased in colorectal cancer and is related to tumor invasiveness and aggressiveness.

Forme physique

Solution in phosphate buffered saline containing 0.02% sodium azide.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Gianluigi Mazzoccoli et al.
Journal of cancer research and clinical oncology, 138(3), 501-511 (2011-12-27)
Cathepsin and plasmin may favor cancer cell invasion degrading extracellular matrix. Plasmin formation from plasminogen is regulated by plasminogen activator inhibitor type-1 (PAI-1). ARNTL2 activates the promoters of the PAI-1 gene, officially called SERPINE1, driving the circadian variation in circulating
K Maemura et al.
The Journal of biological chemistry, 275(47), 36847-36851 (2000-10-06)
The onset of myocardial infarction occurs frequently in the early morning, and it may partly result from circadian variation of fibrinolytic activity. Plasminogen activator inhibitor-1 activity shows a circadian oscillation and may account for the morning onset of myocardial infarction.
John A Schoenhard et al.
American journal of physiology. Cell physiology, 283(1), C103-C114 (2002-06-11)
The BMAL2 gene encodes a member of the basic helix-loop-helix PER-ARNT-SIM family of transcription factors, which control diverse physiological processes including circadian rhythms. We identified four novel human BMAL2 transcripts that differ by alternative splicing within their NH2-terminal regions. Divergent
M Ikeda et al.
Biochemical and biophysical research communications, 275(2), 493-502 (2000-08-31)
We isolated a human cDNA encoding a novel member of the bHLH-PAS transcription factor superfamily, BMAL2, which is highly similar to, but distinct from, BMAL1. The composite cDNA covered a 1720-bp sequence consisting of a putative 1653-bp open reading frame

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