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D0400000

Deoxycorticosterone acetate

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

21-hydroxy-4-pregnène-3,20-dione 21-acétate, 4-Pregnène-21-ol-3,20-dione 21-acétate, Cortexone acétate, DOC acétate

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About This Item

Formule empirique (notation de Hill):
C23H32O4
Numéro CAS:
56-47-3
Poids moléculaire :
372.50
Numéro Beilstein :
2570798
Numéro MDL:
MFCD00003660
Code UNSPSC :
41116107
ID de substance PubChem :
329798604
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

desoxycortone

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@]([H])(CC[C@@]24[H])C(=O)COC(C)=O

InChI

1S/C23H32O4/c1-14(24)27-13-21(26)20-7-6-18-17-5-4-15-12-16(25)8-10-22(15,2)19(17)9-11-23(18,20)3/h12,17-20H,4-11,13H2,1-3H3/t17-,18-,19-,20+,22-,23-/m0/s1

Clé InChI

VPGRYOFKCNULNK-ACXQXYJUSA-N

Informations sur le gène

human ... NR3C2(4306)

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Catégories apparentées

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Desoxycortone acetate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

D Villarreal et al.
The American journal of physiology, 264(4 Pt 2), H1187-H1193 (1993-04-01)
The acute and chronic interactions of the renal nerves, atrial natriuretic factor (ANF), and mineralocorticoids for the regulation of sodium balance were examined in dogs with an arteriovenous (AV) fistula and the syndrome of high-output heart failure (HOHF) (n =
Joseph Fomusi Ndisang et al.
The Journal of pharmacology and experimental therapeutics, 334(1), 87-98 (2010-04-16)
We investigated the role of heme oxygenase (HO), adiponectin, and atrial natriuretic peptide (ANP) in uninephrectomized (UnX) deoxycorticosterone-acetate (DOCA)-salt hypertensive rats, a volume-overload model characterized by elevated endothelin-1 (ET-1), mineralocorticoid-induced oxidative/inflammatory insults, fibrosis, hypertrophy, and severe renal histopathological lesions that
Volker Vallon et al.
Journal of molecular medicine (Berlin, Germany), 84(5), 396-404 (2006-04-11)
The mineralocorticoids aldosterone and deoxycorticosterone acetate (DOCA) stimulate renal tubular salt reabsorption, increase salt appetite, induce extracellular volume expansion, and elevate blood pressure. Cardiac effects of mineralocorticoids include stimulation of matrix protein deposition leading to cardiac fibrosis, which is at
Cleci M Moreira et al.
Clinics (Sao Paulo, Brazil), 67(5), 489-496 (2012-06-06)
Tension cost, the ratio of myosin ATPase activity to tension, reflects the economy of tension development in the myocardium. To evaluate the mechanical advantage represented by the tension cost, we studied papillary muscle contractility and the activity of myosin ATPase
Michael J Morris et al.
Behavioral neuroscience, 124(2), 211-224 (2010-04-07)
Our laboratory has reported that manipulations that provoke a robust sodium appetite (e.g., sodium depletion, deoxycorticosterone acetate) decrease lateral hypothalamic self-stimulation (LHSS) reward if rats are denied access to hypertonic saline solutions. The following studies investigated the interaction between chronic
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