Accéder au contenu
Merck
Toutes les photos(1)

Key Documents

NB20

Sigma-Aldrich

Anti-AnkyrinG Mouse mAb (463)

liquid, ≥95% (SDS-PAGE), clone 463

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(1)

About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

100

Forme d'anticorps

purified antibody

Type de produit anticorps

primary antibodies

Clone

463, monoclonal

Pureté

≥95% (SDS-PAGE)

Forme

liquid

Contient

≤0.1% sodium azide as preservative

Espèces réactives

rat, mouse, human, canine

Fabricant/nom de marque

Calbiochem®

Conditions de stockage

do not freeze

Isotype

IgG1

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... ANK3(288)

Description générale

Anti-Ankyrin G, mouse monoclonal, clone 463, recognizes the ~190 kDa ankyrin G protein in brain extracts. It is validated for Western blotting, immunofluorescence, and frozen sections.
Purified mouse monoclonal antibody generated by immunizing BALB/c mice with the specified immunogen and fusing splenocytes with P3X63/Ag 8.653 mouse myeloma cells. Recognizes the ~190 kDa isoform of AnkyrinG.
Recognizes the ~190 kDa ankyrinG protein in brain extracts. Reacts with all spliced forms of ankyrinG.
  • Antibody Target Gene Symbol: ANK3
  • Target Synonym: 2900054D09RIK, AI314020, AnkG, Ankyrin-3, ANKYRIN-G, FLJ45464, MGC14049
  • Entrez Gene Name: ankyrin 3, node of Ranvier (ankyrin G)
  • Hu Entrez ID: 288 (Related Antibodies: AP1034, PC523, PC522, AP1057)
  • Mu Entrez ID: 11735
  • Rat Entrez ID: 361833

    • Immunogène

    Human
    a synthetic peptide corresponding to amino acids from the spectrin-binding domain of human ankyrinG

    Application


    Frozen Sections (1-2 g/ml)
    Immunoblotting (2-5 g/ml)
    Immunofluorescence (1-2 g/ml)

    Conditionnement

    Please refer to vial label for lot-specific concentration.

    Avertissement

    Toxicity: Standard Handling (A)

    Forme physique

    In 50 mM sodium phosphate buffer, 0.2% gelatin, pH 7.5.

    Remarque sur l'analyse

    Positive Control
    Mouse or rat brain extract or unmyelinated axons

    Autres remarques

    AnkyrinG is a good immunohistochemical marker for axon initial segments, nodes of Ranvier, and epithelial cell-cell contact sites. Antibody should be titrated for optimal results in individual systems.
    Davis, J.Q., et al. 1995. Mol. Biol. Cell6, 177a, supplement.
    Kunimoto, M., et al. 1995. FEBS Lett.357, 217.
    Lambert, S., et al. 1995. Mol. Biol. Cell6, 98a supplement.
    Bennett, V. and Gilligan, D.M. 1993. Ann. Rev. Cell Biol.9, 27.
    Kunimoto, M., et al. 1991. J. Cell Biol.115, 1319.
    Otto, E., et al. 1991. J. Cell Biol.114, 241.
    Davis, J., and Bennett, V. 1984. J. Biol. Chem.259, 13550.

    Informations légales

    CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

    Vous ne trouvez pas le bon produit ?  

    Essayez notre Outil de sélection de produits.

    Code de la classe de stockage

    10 - Combustible liquids

    Classe de danger pour l'eau (WGK)

    nwg

    Point d'éclair (°F)

    Not applicable

    Point d'éclair (°C)

    Not applicable

    Certificats d'analyse (COA)

    Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

    Déjà en possession de ce produit ?

    Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

    Consulter la Bibliothèque de documents

    Dhaval Nanavati et al.
    Journal of neurochemistry, 119(3), 617-629 (2011-08-16)
    Bipolar disorder is a devastating illness that is marked by recurrent episodes of mania and depression. There is growing evidence that the disease is correlated with disruptions in synaptic plasticity cascades involved in cognition and mood regulation. Alleviating the symptoms
    Ruani N Fernando et al.
    Nature communications, 7, 12186-12186 (2016-07-21)
    Fast nerve conduction relies on successive myelin segments that electrically isolate axons. Segment geometry-diameter and length-is critical for the optimization of nerve conduction and the molecular mechanisms allowing this optimized geometry are partially known. We show here that peripheral myelin
    Hongyan Zhu et al.
    Scientific reports, 6, 38108-38108 (2016-12-03)
    Voltage-gated sodium channels (VGSCs) play a vital role in controlling neuronal excitability. Nav1.6 is the most abundantly expressed VGSCs subtype in the adult central nervous system and has been found to contribute to facilitate the hyperexcitability of neurons after electrical
    Wing Yan Yu et al.
    Stem cells and development, 24(5), 624-639 (2014-10-18)
    A growing body of evidence has revealed that stem-like cells in the posterior limbus of the eye between the corneal endothelium (CE) and trabecular meshwork (TM) may be able to rejuvenate these tissues in disease. However, these cells have not

    Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

    Contacter notre Service technique