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Merck
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Key Documents

MABN762

Sigma-Aldrich

Anti-VSNL1 Antibody, clone 2D11

clone 2D11, from mouse

Synonyme(s) :

Visinin-like protein 1, VILIP, VLP-1, Hippocalcin-like protein 3, HLP3

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

100

Forme d'anticorps

purified antibody

Type de produit anticorps

primary antibodies

Clone

2D11, monoclonal

Espèces réactives

bovine, rat, mouse, human

Technique(s)

immunohistochemistry: suitable
western blot: suitable

Isotype

IgG2bκ

Numéro d'accès NCBI

NP_003376

Numéro d'accès UniProt

P62760

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... VSNL1(7447)

Description générale

The protein VSNL1, Visinin-like protein 1 (VILIP, or VLP-1), or Hippocalcin-like protein 3 (HLP3) and encoded by the gene VSNL1/VISL1, is a calcium sensor protein that regulates calcium signaling pathways in neurons. In the retina VSNL1 regulates the inhibition of rhodopsin phosphorylation. VSNL1 is expressed specifically in the brain (and is particularly strong in the granule cells of the cerebellum), retina and PNS. VSNL1 levels are up regulated in Alzheimer′s disease but the significance is unknown at present. VSNL1 belongs to the recoverin family of neuronal specific proteins. Interestingly, new research seems so argue that VSHL1 can also be expressed by non-neuronal cells such as epidermal cells and may play a role as a tumor suppressor gene in squamous carcinoma cells and skin cancer.

Immunogène

Recombinant protein corresponding to human VSNL1.

Application

Detect VSNL1 using this Anti-VSNL1 Antibody, clone 2D11 validated for use in western blotting & IHC.
Western Blotting Analysis: 0.5 µg/mL from a representative lot detected VSNL1 in 10 µg of human cerebellum, rat brain, and mouse cerebellum tissue lysate.
Immunohistochemistry Analysis: A representative lot detected VSNL1 in rat cerebellar cortex tissue (courtesy from the laboratory of Gerry Shaw).

Qualité

Evaluated by Western Blotting in mouse brain tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected VSNL1 in 10 µg of mouse brain tissue lysate.

Description de la cible

~22 kDa observed

Forme physique

Format: Purified
Purified mouse monoclonal IgG2bκ in buffer containing PBS with 0.05% sodium azide.

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Juilee Rege et al.
Journal of the Endocrine Society, 4(10), bvaa123-bvaa123 (2020-10-10)
Somatic mutations driving aldosterone production have been identified in approximately 90% of aldosterone-producing adenomas (APAs) using an aldosterone synthase (CYP11B2) immunohistochemistry (IHC)-guided DNA sequencing approach. In the present study, using CYP11B2-guided whole-exome sequencing (WES) and targeted amplicon sequencing, we detected
Jessica E Baker et al.
Molecular and cellular endocrinology, 530, 111296-111296 (2021-04-30)
Adequate access to fresh or frozen normal adrenal tissue has been a primary limitation to the enhanced characterization of the adrenal zones via RNA sequencing (RNAseq). Herein, we describe the application of targeted RNAseq to formalin-fixed paraffin-embedded (FFPE) normal adrenal
Vivek Swarup et al.
Nature medicine, 25(1), 152-164 (2018-12-05)
Identifying the mechanisms through which genetic risk causes dementia is an imperative for new therapeutic development. Here, we apply a multistage, systems biology approach to elucidate the disease mechanisms in frontotemporal dementia. We identify two gene coexpression modules that are

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