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MAB5492

Sigma-Aldrich

Anti-Huntingtin Antibody, a.a. 1-82

ascites fluid, clone 2B4, Chemicon®

Synonyme(s) :

Anti-Huntingtin, Anti-Huntingtin Antibody, Detection Antibody

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

100

Forme d'anticorps

ascites fluid

Type de produit anticorps

primary antibodies

Clone

2B4, monoclonal

Espèces réactives

human

Fabricant/nom de marque

Chemicon®

Technique(s)

ELISA: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

Isotype

IgG1

Numéro d'accès NCBI

NM_002111.6

Numéro d'accès UniProt

P42858

Conditions d'expédition

dry ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... HTT(3064) , SLC6A4(6532)

Spécificité

Reacts huntingtin protein, amino acids 1-82. The antibody recognizes wild type and mutant huntingtin.

Immunogène

Epitope: a.a. 1-82
Recombinant human huntingtin, amino acids 1-82.

Application

Anti-Huntingtin Antibody, a.a. 1-82 is an antibody against Huntingtin for use in ELISA, IC, IH & WB.
Research Category
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Western blot: 1:500-1:5,000

Immunocytochemistry (1): 1:500-1:5,000

Immunohistochemistry (1,2): 1:500-1:5,000

ELISA: 1:500-1:5,000

Optimal working dilutions must be determined by end user.

Description de la cible

348 kDa

Forme physique

Ascites fluid containing no preservatives.
Unpurified

Stockage et stabilité

Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Remarque sur l'analyse

Control
Normal human cerebral cortex lysate, Mouse brain cortex samples from HD or wild type mice

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informations légales

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Réf. du produit
Description
Tarif

Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Acetylation targets mutant huntingtin to autophagosomes for degradation.
Hyunkyung Jeong,Florian Then,Thomas J Melia,Joseph R Mazzulli,Libin Cui,Jeffrey N Savas et al.
Cell null
Jonathan H Fox et al.
The Journal of biological chemistry, 286(20), 18320-18330 (2011-04-02)
Huntington disease (HD) is a progressive neurodegenerative disorder caused by expression of polyglutamine-expanded mutant huntingtin protein (mhtt). Most evidence indicates that soluble mhtt species, rather than insoluble aggregates, are the important mediators of HD pathogenesis. However, the differential roles of
Xiaofeng Gu et al.
Neuron, 85(4), 726-741 (2015-02-11)
The nucleus is a critical subcellular compartment for the pathogenesis of polyglutamine disorders, including Huntington's disease (HD). Recent studies suggest the first 17-amino-acid domain (N17) of mutant huntingtin (mHTT) mediates its nuclear exclusion in cultured cells. Here, we test whether
Inducing huntingtin inclusion formation in primary neuronal cell culture and in vivo by high-capacity adenoviral vectors expressing truncated and full-length huntingtin with polyglutamine expansion.
Bin Huang, Johannes Schiefer, Christian Sass, Christoph M Kosinski, Stefan Kochanek
The journal of gene medicine null
The composition of the polyglutamine-containing proteins influences their co-aggregation properties.
Bak D, Milewski M
Cell Biology International null
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