MAB2170
Anti-Huntingtin Protein Antibody, a.a. 1247-1646, clone HU-4E6
ascites fluid, clone HU-4E6, Chemicon®
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About This Item
Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
mouse
Niveau de qualité
Forme d'anticorps
ascites fluid
Type de produit anticorps
primary antibodies
Clone
HU-4E6, monoclonal
Espèces réactives
mouse, human
Fabricant/nom de marque
Chemicon®
Technique(s)
ELISA: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable (paraffin)
immunoprecipitation (IP): suitable
western blot: suitable
Isotype
IgG2b
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
dry ice
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... HTT(3064) , SLC6A4(6532)
Spécificité
Huntingtin Protein. No detectable cross reactivity with other proteins by Western blot.
Immunogène
Epitope: a.a. 1247-1646
Huntingtin fragment from aa 1247 to 1646 as a fusion protein
Application
Detect Huntingtin Protein using this Anti-Huntingtin Protein Antibody, a.a. 1247-1646, clone HU-4E6 validated for use in ELISA, IP, WB, IC, IH(P).
ELISA: 1:500-1:5,000
Western blot (recombinant protein, not suitable for the natural Huntingtin) : 1:500-1:5,000
Immunohistochemistry on frozen and microwave oven treated paraffin sections (human): 1:500-1:5,000
Immunocytochemistry on transfected cells: 1:500-1:5,000
Immunoprecipitation: 1:500-1:5,000
Optimal working dilutions must be determined by the end user.
Western blot (recombinant protein, not suitable for the natural Huntingtin) : 1:500-1:5,000
Immunohistochemistry on frozen and microwave oven treated paraffin sections (human): 1:500-1:5,000
Immunocytochemistry on transfected cells: 1:500-1:5,000
Immunoprecipitation: 1:500-1:5,000
Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Neurodegenerative Diseases
Forme physique
Ascites fluid. Liquid, does not contain any preservative.
Stockage et stabilité
Maintain at -20°C in undiluted aliquots up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.
During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For antibodies with volumes of 200 μl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container′s cap.
During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For antibodies with volumes of 200 μl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container′s cap.
Informations légales
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Réf. du produit
Description
Tarif
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
nwg
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Molecular cloning and characterization of the common marmoset huntingtin gene.
Hirohiko Hohjoh,Hirofumi Akari,Yuko Fujiwara,Yoshiko Tamura,Hirohisa Hirai,Keiji Wada
Gene null
Neurons lacking huntingtin differentially colonize brain and survive in chimeric mice.
A Reiner, N Del Mar, C A Meade, H Yang, I Dragatsis, S Zeitlin, D Goldowitz
The Journal of Neuroscience null
Anjalika Chongtham et al.
Human molecular genetics, 29(4), 674-688 (2020-01-17)
Huntington's disease (HD) is caused by an expansion of a poly glutamine (polyQ) stretch in the huntingtin protein (HTT) that is necessary to cause pathology and formation of HTT aggregates. Here we ask whether expanded polyQ is sufficient to cause
Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner.
Benn, CL; Sun, T; Sadri-Vakili, G; McFarland, KN; DiRocco, DP; Yohrling, GJ; Clark et al.
The Journal of Neuroscience null
F R Fusco et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 19(4), 1189-1202 (1999-02-10)
Immunohistochemistry and single-cell RT-PCR were used to characterize the localization of huntingtin and/or its mRNA in the major types of striatal neurons and in corticostriatal projection neurons in rats. Single-label immunohistochemical studies revealed that striatum contains scattered large neurons rich
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