8.55140

Fmoc-PAL-Linker

Novabiochem^®

• Synonyme(s) : Fmoc-PAL-Linker
• Formule empirique (notation de Hill): C₂₉H₃₁NO₇
• Numéro CAS: 115109-65-4
• Poids moléculaire : 505.56
• Code UNSPSC : 12352209
• Nomenclature NACRES : NA.22

Propriétés

• Niveau de qualité: 200
• Gamme de produits: Novabiochem^®
• Forme: solid
• Pertinence de la réaction: reagent type: linker
• Fabricant/nom de marque: Novabiochem^®
• Pf: 178-180 °C
• Application(s): peptide synthesis
• Groupe fonctionnel: Fmoc
• Température de stockage: 2-8°C
• InChI: 1S/C29H31NO7/c1-34-26-15-19(36-14-8-7-13-28(31)32)16-27(35-2)24(26)17-30-29(33)37-18-25-22-11-5-3-9-20(22)21-10-4-6-12-23(21)25/h3-6,9-12,15-16,25H,7-8,13-14,17-18H2,1-2H3,(H,30,33)(H,31,32)
• Clé InChI: ATYUCXIJDKHOPX-UHFFFAOYSA-N

Description

Description générale

Barany′s aminomethyl-dimethoxyphenoxyvaleric acid linker ^[1]. The amino group of this linker can be easily acylated under standard coupling conditions. Following peptide assembly, treatment with 95% TFA containing scavengers releases the desired peptide amide. Studies have shown the acid sensitivity of this linker to be around twice that of the Rink amide linker ^[2]. There is some evidence to suggest that PAL resins give greater yields in microwave assisted synthesis.

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Remarque sur l'analyse

Color (visual): white to beige to grey
Appearance of substance (visual): powder
Identity (IR): passes test
Purity (TLC(0811)): ≥ 98.0 %
Assay (HPLC, area%): ≥ 95.0 % (a/a)

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Informations légales

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable