574714

BAY 61-3606

≥97% (HPLC), solid, Syk inhibitor, Calbiochem^®

• Synonyme(s) : Syk Inhibitor IV, BAY 61-3606, 2-(7-(3,4-Dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino)-nicotinamide, HCl, BAY 61-3606
• Formule empirique (notation de Hill): C₂₀H₁₈N₆O₃ · xHCl · yH₂O
• Numéro CAS: 732983-37-8
• Poids moléculaire : 390.40 (anhydrous free base basis)
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• product name: Syk Inhibitor IV, BAY 61-3606, The Syk Inhibitor IV, BAY 61-3606, also referenced under CAS 732938-37-8, controls the biological activity of Syk. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
• Niveau de qualité: 100
• Pureté: ≥97% (HPLC)
• Forme: solid
• Puissance: 10 nM IC₅₀
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic); protect from light
• Couleur: yellow
• Solubilité: DMSO: 10 mg/mL; water: 20 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• InChI: 1S/C20H18N6O3/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24-14)25-19-13(18(21)27)4-3-7-23-19/h3-11H,1-2H3,(H2,21,27)(H,23,24,25)
• Clé InChI: JWQOJVOKBAAAAR-UHFFFAOYSA-N

Description

Description générale

A cell-permeable imidazopyrimidine compound that acts a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (IC₅₀ = 10 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src even at concentrations as high as 4.7 µM. Shown to inhibit Syk-mediated cellular functions in vitro and exhibit good oral bioavailability and in vivo effacacy in the treatment of various allgery and asthma conditions in rat models.

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
Syk

Product competes with ATP.

Reversible: yes

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Yamamoto, N., et al. 2003. J. Pharm. Exp. Ther.306, 1174.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable