573108-M

STAT5 Inhibitor

The STAT5 Inhibitor, also referenced under CAS 285986-31-4, controls the biological activity of STAT5.

• Synonyme(s) : STAT5 Inhibitor, Nʹ-((4-Oxo-4H-chromen-3-yl)methylene)nicotinohydrazide
• Formule empirique (notation de Hill): C₁₆H₁₁N₃O₃
• Numéro CAS: 285986-31-4
• Poids moléculaire : 293.28
• Code UNSPSC : 12352200

Propriétés

• Niveau de qualité: 100
• Pureté: ≥97% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: white
• Solubilité: DMSO: 25 mg/mL
• Température de stockage: 2-8°C

Description

Description générale

A cell-permeable nonpeptidic nicotinoyl hydrazone compound that selectively targets the SH2 domain of STAT5 (IC₅₀ = 47 µM against STAT5b SH2 domain EPO peptide binding activity), while exhibiting much less effect towards the SH2 domain of STAT1, STAT3, or Lck (IC₅₀ >500 µM). Shown to block STAT5/STAT5 DNA binding activity in K562 nuclear extract and inhibit IFN-α-stimulated STAT5, but not STAT1 or STAT3, tyrosine phosphorylation in Daudi cells.

Avertissement

Toxicity: Standard Handling (A)

Autres remarques

Muller, J., et al. 2008. ChemBioChem9, 723.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable