572636

SU6656

InSolution, ≥95%, inhibitor of Src-family protein tyrosine kinases

• Synonyme(s) : InSolution SU6656
• Formule empirique (notation de Hill): C₁₉H₂₁N₃O₃S
• Poids moléculaire : 371.45
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (HPLC)
• Forme: liquid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic); protect from light
• Conditions d'expédition: wet ice
• Température de stockage: 2-8°C

Description

Description générale

A potent inhibitor of Src-family protein tyrosine kinases. Inhibits Src (IC₅₀ = 280 nM) as well as closely related kinases Fyn (IC₅₀ = 170 nM), Yes (IC₅₀ = 20 nM) and Lyn (IC₅₀ = 130 nM). The inhibition is competitive with respect to ATP. Has only a trivial effect on Lck (IC₅₀ = 6.88 µM). Does not affect the activity of PDGF-β receptor kinase (IC₅₀ >10 µM) and IGF-1 receptor kinase (IC₅₀ gt;20 µM).

Actions biochimiques/physiologiques

Cell permeable: yes

Product competes with ATP.

Reversible: yes

Target IC₅₀: 280 nM inhibiting Src

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Irritant (B)

Forme physique

A 10 mM (500 µg/135 µl) solution of SU6656 (Cat. No. 572635) in DMSO.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): 188.6 °F - closed cup - (Dimethylsulfoxide)
• Point d'éclair (°C): 87 °C - closed cup - (Dimethylsulfoxide)