572635

SU6656

A potent, cell-permeable, reversible, and ATP-competitive Src family kinase inhibitor.

• Synonyme(s) : SU6656
• Formule empirique (notation de Hill): C₁₉H₂₁N₃O₃S
• Numéro CAS: 330161-87-0
• Poids moléculaire : 371.45
• Numéro MDL: MFCD10565928
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥97% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: burnt orange
• Solubilité: DMSO: 25 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• InChI: 1S/C19H21N3O3S/c1-22(2)26(24,25)14-7-8-18-15(11-14)16(19(23)21-18)10-13-9-12-5-3-4-6-17(12)20-13/h7-11,20H,3-6H2,1-2H3,(H,21,23)/b16-10+
• Clé InChI: LOGJQOUIVKBFGH-MHWRWJLKSA-N

Description

Description générale

A potent, cell-permeable, reversible, and ATP-competitive Src family kinase inhibitor. Inhibits Src (IC₅₀ = 280 nM) as well as closely related kinases such as Fyn (IC₅₀ = 170 nM) and Yes (IC₅₀ = 20 nM) and Lyn (IC₅₀ = 130 nM). Acts as a weak inhibitor of Lck (IC₅₀ = 688 µM) and PDGF receptor kinase (IC₅₀ >10 µM). A 10 mM (500 µg/135 µl) solution of SU6656 (Cat. No. 572636) in DMSO is also available.

A potent, cell-permeable, reversible, and ATP-competitive inhibitor of Src-family protein tyrosine kinases. Inhibits Src (IC₅₀ = 280 nM) as well as closely related kinases Fyn (IC₅₀ = 170 nM), Yes (IC₅₀ = 20 nM) and Lyn (IC₅₀ = 130 nM). The inhibition is competitive with respect to ATP. Has only a trivial effect on Lck (IC₅₀ = 6.88 µM). Does not affect the activity of PDGF-β receptor kinase (IC₅₀ ≥10 µM) and IGF-1 receptor kinase (IC₅₀ ≥20 µM).

Actions biochimiques/physiologiques

Cell permeable: yes

Product competes with ATP.

Reversible: yes

Target IC₅₀: 280 nM, 170 nM, 20 nM, and 130 nM against Src, Fyn, Yes, and Lyn.

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Autres remarques

Bowman, T., et al. 2001. Proc. Natl. Acad. Sci. USA98, 7319.
Blake, R.A., et al. 2000. Mol. Cell. Biol.20, 9018.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable