5.43899

NMP

for liquid chromatography LiChrosolv^®

• Synonyme(s) : 1-Methyl-2-pyrrolidone, NMP, N-Methyl-2-pyrrolidone
• Formule empirique (notation de Hill): C₅H₉NO
• Numéro CAS: 872-50-4
• Poids moléculaire : 99.13
• Numéro MDL: MFCD00003193
• Code UNSPSC : 41116105
• Numéro de classement CE : 212-828-1
• Nomenclature NACRES : NA.03

Propriétés

• product name: 1-Methyl-2-pyrrolidone, for liquid chromatography LiChrosolv^®
• Pression de vapeur: 0.32 hPa ( 20 °C)
• Niveau de qualité: 100
• Gamme de produits: LiChrosolv^®
• Qualité: isocratic
• Pureté: ≥99.5% (GC)
• Forme: liquid
• Température d'inflammation spontanée: 245 °C
• Limite d'explosivité: 1.3-9.5 % (v/v)
• Technique(s): HPLC: suitable
• Impuretés: ≤0.05% Water
• Transmittance: 300 nm, ≥50%; 325 nm, ≥90%; 350 nm, ≥97%; 400 nm, ≥99%
• pH: 8.5-10.0 (20 °C, 100 g/L in H₂O)
• Point d'ébullition: 202 °C/1013 hPa
• Pf: -24 °C
• Température de transition: flash point 91 °C
• Solubilité: 1000 g/L
• Densité: 1.03 g/cm³ at 20 °C
• Température de stockage: 2-30°C
• InChI: 1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3
• Clé InChI: SECXISVLQFMRJM-UHFFFAOYSA-N

Description

Application

• Novel transdermal bioadhesive surfactant-based system for release and solubility improvement of antimalarial drugs artemether-lumefantrine: This study utilizes 1-Methyl-2-pyrrolidone (NMP) as a high-purity solvent in the formulation of a transdermal bioadhesive system, enhancing the solubility and delivery of antimalarial drugs. The application highlights NMP′s role in pharmaceutical formulations, particularly in improving drug efficacy and patient compliance (Volpe-Zanutto et al., 2021).

Remarque sur l'analyse

Purity (GC): ≥ 99.5 %
Water: ≤ 0.05 %
Transmission (at 300 nm): ≥ 50 %
Transmission (at 325 nm): ≥ 90 %
Transmission (at 350 nm): ≥ 97 %
Transmission (at 400 nm): ≥ 99 %

Autres remarques

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Informations légales

LICHROSOLV is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS07,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H315 - H319 - H335 - H360D
• Conseils de prudence: P202 - P261 - P264 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Classification des risques: Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): 195.8 °F - Pensky-Martens closed cup
• Point d'éclair (°C): 91 °C - Pensky-Martens closed cup