5.06271

Ketanserin Tartrate

• Synonyme(s) : Ketanserin Tartrate, 5-HT _2A Serotonin Receptor Antagonist, Ketanserin, R 41 468
• Formule empirique (notation de Hill): C₂₂H₂₂FN₃O₃ · xC₄H₆O₆
• Numéro CAS: 83846-83-7
• Poids moléculaire : 395.43 (free base basis)
• Numéro MDL: MFCD00084651
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥97% (HPLC)
• Niveau de qualité: 100
• Forme: solid
• Puissance: 1.49 nM K_i
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: white
• Solubilité: DMSO: soluble
• Température de stockage: 2-8°C
• InChI: 1S/C22H22FN3O3.C4H6O6.H2O/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29;5-1(3(7)8)2(6)4(9)10;/h1-8,16H,9-14H2,(H,24,29);1-2,5-6H,(H,7,8)(H,9,10);1H2
• Clé InChI: KJJRKCWDAHTVRL-UHFFFAOYSA-N

Description

Description générale

A selective 5-HT_2A serotonin receptor antagonist with weak adrenergic receptor blocking properties. Strong affinity for 5-HT_2AR (K_i = 1.49 nM) relative to other family members like 5-HT_2BR (K_i = 740 nM) and 5-HT_2CR (K_i = 59 nM). Often used in conjunction with SB 206553 to distinguish 5-HT_2AR and 5-HT_2CR activity.

A selective 5-HT_2A serotonin receptor antagonist with weak adrenergic receptor blocking properties. Strong affinity for 5-HT_2AR (K_i = 1.49 nM) relative to other family members like 5-HT_2BR (K_{i = 740 nM) and 5-HT2CR (Ki = 59 nM). Often used in conjunction with SB 206553 to distinguish 5-HT2AR and 5-HT2CR activity.}

Actions biochimiques/physiologiques

Primary Target
5-HT_2A

Avertissement

Toxicity: Toxic (F)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Ros, R. et al. 2013. PNAS.110, 348.

Knight, A. R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114.
Aloyo, V. J. and Harvey, J. A. 2000. Eur. J. Pharmacol.406, 163.
Leysen, J. E. et al. 1981. Life Sci.28, 1015.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H301
• Conseils de prudence: P264 - P270 - P301 + P310 - P405 - P501
• Classification des risques: Acute Tox. 3 Oral
• Code de la classe de stockage: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable