936545

Thalidomide-NH-PEG2-COOH

≥95%

• Synonyme(s) : 3-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)ethoxy)ethoxy)propanoic acid, 3-[2-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]ethoxy]ethoxy]propanoic acid, Propanoic acid, 3-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]ethoxy]ethoxy]-
• Formule empirique (notation de Hill): C₂₀H₂₃N₃O₈
• Numéro CAS: 2412056-45-0
• Poids moléculaire : 433.41
• Numéro MDL: MFCD34368531
• Code UNSPSC : 12352106
• Nomenclature NACRES : NA.22

Propriétés

• ligand: thalidomide
• Niveau de qualité: 100
• Essai: ≥95%
• Forme: powder or crystals (or Solid or Chunks)
• Couleur: faint yellow to yellow, and Yellow-Green
• Température de stockage: 2-8°C
• Chaîne SMILES: O=C(O)CCOCCOCCNC1=CC=C2C(=O)N(C(=O)C2=C1)C3C(=O)NC(=O)CC3

Description

Application

Thalidomide-NH-PEG2-COOH is a functionalized von-Hippel-Lindau (VHL) ligand with a terminal hydroxyl group. Allows rapid conjugation with many linkers containing active leaving groups. A basic building block for development of a protein degrader library.

Technology Spotlight:

Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks

Autres remarques

Targeted Protein Degradation by Small Molecules
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs

Informations légales

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Informations sur la sécurité

• Pictogrammes: GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H301,H312,H360D
• Conseils de prudence: P202 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P362 + P364
• Classification des risques: Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Repr. 1A
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable