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764787

Sigma-Aldrich

Poly(lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(lactide-co-glycolide)

average Mn (1,000-1,000-1,000), lactide:glycolide 50:50

Synonyme(s) :

PLGA-PEG-PLGA

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About This Item

Code UNSPSC :
12162002
Nomenclature NACRES :
NA.23

Description

typical PEG PDI<1.1; overall PDI<1.2 (THF, PEO)

Forme

liquid

Ratio alimentaire

lactide:glycolide 50:50

Poids mol.

PEG average Mn 1,000
PLGA average Mn 2000
average Mn (1,000-1,000-1,000)

Intervalle de dégradation

1-2 weeks

PDI

<1.2

Température de stockage

2-8°C

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Description générale

PLGA-PEG-PLGA is an amphiphilic triblock copolymer which can self-assemble into micelles in aqueous medium due to the hydrophobic interactions present in the hydrophobic segments. The PEG segment imparts hydrophilicity and improves the biocompatibility of the copolymer. The PLGA segment forms a hydrophobic core and can solubilize hydrophobic drugs. These copolymers are widely used as nanocarriers for the sustained release of drugs.

Application

Used in the synthesis of targeted nanoparticles which are used for differential delivery and controlled release of drugs.

Caractéristiques et avantages

Biocompatible, degradable, thermosensitive, high stability, small size (<200 nm) and properties can be easily modified.

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
MKCN7068
MKCG6095
MKCC8982
MKBX1132V
MKBT6439V

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The aim of this study was to assess the potential of new copolymeric micelles to modify the pharmacokenetics and tissue distribution of Curcumin (CUR), a hydrophobic drug. In the present study, a poly (d,l-lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(d,l-lactide-co-glycolide) (PLGA-PEG-PLGA) copolymer was synthesized and
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Proceedings of the National Academy of Sciences of the United States of America, 105(7), 2586-2591 (2008-02-15)
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